1. A lipid arsenal to control inflammation
by Brooke A. Napier, and Denise M. Monack
Science
Volume 352(6290):
June 3, 2016
Published by AAAS

2. Hyperactivating lipids.
Hyperactivating lipids. During infection, dendritic cells detect the presence of microbial lipopolysaccharide (LPS) and host-derived oxidized phospholipids (oxPAPC) that are released from damaged and dying cells. oxPAPC binds to CD14, enters the host cell through an unknown mechanism, and then binds to caspase-11, inducing secretion of proinflammatory IL-1β and inhibiting cell death. These hyperactive dendritic cells also activate T cells, enhancing protective adaptive immunity from the infecting microbe.
Brooke A. Napier, and Denise M. Monack Science 2016;352:
Published by AAAS