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Published byἈλεξανδρεύς Ζάρκος Modified over 5 years ago
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The initiation and progression of sickle cell nephropathy
Donald E. Wesson Kidney International Volume 61, Issue 6, Pages (June 2002) DOI: /j x Copyright © 2002 International Society of Nephrology Terms and Conditions
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Figure 1 (A) Glomerulus from a patient with sickle cell disease (right) is much larger than one from an age-matched control (left) at the same magnification. (B) Glomerular area indicated on the ordinate is significantly larger in sickle cell patients than control. From Ref. 13. Kidney International , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions
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Figure 2 Compared to normal, the transgenic mouse model of sickle cell disease produces higher levels of ethane, a measure of the production of reactive oxygen species. This increase is most evident after the animals are reoxygenated (▪) following hypoxia; () the baseline period. From Ref. 67. Kidney International , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions
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Figure 3 Emigration of leukocytes is greater following hypoxia/reoxygenation in the transgenic mouse model of sickle cell disease () than in controls (▪). From Ref. 14. Kidney International , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions
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Kidney International 2002 61, 2277-2286DOI: (10. 1046/j. 1523-1755
Kidney International , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions
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