1. Participation of cell cycle regulators in the different stages of adipogenesis.
Participation of cell cycle regulators in the different stages of adipogenesis. During the clonal expansion phase of adipocyte differentiation E2F1 regulates the expression of genes implicated in the entry of the cells into cell cycle. In addition, E2F1 regulates, at this stage the expression of the master regulator of adipogenesis, PPARγ. pRB represses E2F1 activity, whereas cdk4 represses pRB, and therefore activates E2F1. In terminal differentiation cyclins and cyclin‐dependent kinases still participate in the biology of adipocytes through regulation of the activity of PPARγ in an E2F‐independent manner. pRB can also directly repress PPARγ activity at this stage.
Victor Aguilar, and Lluis Fajas EMBO Mol Med. 2010;2:
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