Presentation is loading. Please wait.

Presentation is loading. Please wait.

Norman A. Shoenfeld, M. D. , Jens Eldrup-Jorgensen, M. D

Similar presentations


Presentation on theme: "Norman A. Shoenfeld, M. D. , Jens Eldrup-Jorgensen, M. D"— Presentation transcript:

1 The effect of low molecular weight dextran on platelet deposition onto prosthetic materials 
Norman A. Shoenfeld, M.D., Jens Eldrup-Jorgensen, M.D., Raymond Connolly, Ph.D., Allan D. Callow, M.D., Ph.D., C.Robert Valeri, M.D., Karen Ramberg, M.S., William C. Mackey, M.D., Thomas F. O'Donnell, M.D.  Journal of Vascular Surgery  Volume 5, Issue 1, Pages (January 1987) DOI: / (87) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 The baboon ex vivo shunt.
Journal of Vascular Surgery 1987 5, 76-82DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 Effect of dextran on platelet deposition onto Dacron grafts. Error bars represent ± one standard error. Difference between both groups is significant (p < 0.05) at all time points. Journal of Vascular Surgery 1987 5, 76-82DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 Effect of dextran on platelet deposition onto polytetrafluoroethylene (PTFE) grafts. Difference between two groups is significant at all time points (p < 0.05). Journal of Vascular Surgery 1987 5, 76-82DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5 Fig. 4 Effect of plasma volume expansion with albumin on platelet deposition onto Dacron and PTFE grafts. No significant difference is present between albumin and control groups. Journal of Vascular Surgery 1987 5, 76-82DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

6 Fig. 5 Platelet deposition on Dacron and PTFE. Plasma volume expansion with albumin vs. dextran. Difference between albumin and LMD groups is significant (p < 0.05) for both materials at all time points. Journal of Vascular Surgery 1987 5, 76-82DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

7 Fig. 6 Dextran-mediated inhibition of platelet deposition (as compared with 5% albumin infusion). Journal of Vascular Surgery 1987 5, 76-82DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

8 Fig. 7 A and C. Scanning electron micrograph of PTFE graft removed at 2½ hours from baboon ex vivo shunt after albumin infusion. Note fibrin network formed and prominent platelet aggregates. B and D. PTFE graft after dextran infusion. Structure of underlying graft is clearly seen, with absence of platelets and fibrin compared with the albumin shunt. (Original magnification A and B × 1000; C and D × 4000.) Journal of Vascular Surgery 1987 5, 76-82DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions


Download ppt "Norman A. Shoenfeld, M. D. , Jens Eldrup-Jorgensen, M. D"

Similar presentations


Ads by Google