Presentation is loading. Please wait.

Presentation is loading. Please wait.

A Presentation by Regina Strelecki

Similar presentations


Presentation on theme: "A Presentation by Regina Strelecki"— Presentation transcript:

1 A Presentation by Regina Strelecki
Metagenomics A Presentation by Regina Strelecki

2 Nat Rev Microbiol 2015 June; 13(6): 360-372
Next-Generation Approaches to Understand and Combat the Antibiotic Resistome Crofts, T. S.; Gasparrini, A. J.; Dantas, G. Nat Rev Microbiol 2017 Jul; 15(7): Sequencing and Beyond: Integrating Molecular ‘Omics for Microbial Community Profiling Franzosa, E. A.; Hsu, T.; Sirota-Madi, A.; Shafquat, A.; Abu-Ali, G.; Morgan, X. C.; Huttenhower, C. Nat Rev Microbiol 2015 June; 13(6):

3 Bacterial Strategies to Resist Antibiotics
Nat Rev Microbiol 2017 Jul; 15(7):

4 Cross-Habitat Resistome Study Provides Historical Record of Past Mobility of TEM-1
Pehrsson, E.C., et al. Nature. 2016, 533,

5 The First Evidence of the Sharing of Multidrug Resistance Gene Cassettes Between Non-Pathogenic Soil Bacteria and Human Pathogens Forsberg, K.J., et al. Science. 2012, 337,

6 Global Spread of Plasmid-Borne Resistance
Nat Rev Microbiol 2017 Jul; 15(7):

7 Next-Generation Sequencing and Functional Metagenomic Selection Catalogue Known and Novel Resistance Genes Nat Rev Microbiol 2017 Jul; 15(7):

8 A Survey of Resistance Proteins in the UniProt Database: Tetracycline Efflux Pumps, β-Lactamases, Chloramphenicol Acetyltransferases UniProt Consortium. Nucleic Acids Res. 2015, 43, D204-D212

9 Functional Metagenomics 1
Functional Metagenomics 1. Ascribes a Resistance Function to Known Genes Discovers Resistance Genes with Novel Sequences Gibson, M.K., et al. Nat. Microbiol. 2016, 1, 16024

10 Functional Metagenomic Investigation in a Human-Associated Resistome: 10 Novel β-Lactamases Identified in 2 Gut Microbiomes Sommer, MO; Dantas, G.; Church, GM. Science. 2009, 325,

11 Characterization of Resistomes by Pairing Functional Metagenomic Selection with Next-Generation Sequencing Adu-Oppong, B.;Gasparrini, A. J.;Dantas, G. Ann NY Acad Sci. 2017, 1388, 42-58

12 The Integration of Next-Generation Sequencing and Screening Technologies with Drug Development and Resistance Surveillance Nat Rev Microbiol 2017 Jul; 15(7):

13 New Considerations Microbiome Experimental Design
Nat Rev Microbiol 2015 June; 13(6):

14 Combining WMS and Amplicon Sequencing
Nat Rev Microbiol 2015 June; 13(6):

15 Mapping Metagenomic Paired-End Sequencing Reads to Reference Genomes Detects Strain Variation
Nat Rev Microbiol 2015 June; 13(6):

16 Longitudinal Studies (Time Course Analysis) of Strain Variation
Nat Rev Microbiol 2015 June; 13(6):

17 Metagenomic Assembly Detects Strain Variation
Nat Rev Microbiol 2015 June; 13(6):

18 Relating the Metatranscriptome and Metagenome in the Human Gut
Franzosa, E.A.; et al. Proc Natl Acad Sci U S A. 2014, 111, E

19 Integrative Analysis of a Microbiome Sample Provides Information about the Copy Numbers and Activities of Genes Nat Rev Microbiol 2015 June; 13(6):

20 Multi’omic Data Integration Normalizes Transcript Abundance by Gene Copy Number
Nat Rev Microbiol 2015 June; 13(6):

21 Multi’omic Data Integration Provides Stronger Collective Support for a Hypothesis
Nat Rev Microbiol 2015 June; 13(6):

22 Multi’omic Data Integration Enables Descriptive Modeling
Nat Rev Microbiol 2015 June; 13(6):


Download ppt "A Presentation by Regina Strelecki"

Similar presentations


Ads by Google