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Enhanced CD46-induced regulatory T cells suppress allergic inflammation after Dermatophagoides pteronyssinus–specific immunotherapy  Yi-Giien Tsai, MD,

Published by衬毖恤 米 Modified over 5 years ago

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Presentation on theme: "Enhanced CD46-induced regulatory T cells suppress allergic inflammation after Dermatophagoides pteronyssinus–specific immunotherapy  Yi-Giien Tsai, MD,"— Presentation transcript:

1 Enhanced CD46-induced regulatory T cells suppress allergic inflammation after Dermatophagoides pteronyssinus–specific immunotherapy  Yi-Giien Tsai, MD, PhD, Jui-Chung Lai, MD, Kuender D. Yang, MD, PhD, Chih-Hsing Hung, MD, PhD, Ya-Ju Yeh, MS, Ching-Yuang Lin, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 134, Issue 5, Pages e1 (November 2014) DOI: /j.jaci Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Significant increases in IL-10 (A) and IFN-γ (B) production were observed in CD3/CD46-activated CD4+ T cells after 12 months of SIT (n = 30). C and D, Quantitative RT-PCR analysis of Cyt1 mRNA and Cyt2 mRNA expression in CD4+ T cells by CD3/CD46 stimulation. Increased Cyt1 mRNA (Fig 1, C) and decreased Cyt2 mRNA (Fig 1, D) expression were noted in post-SIT status (n = 30). *Mean P < .05. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 A and B, There was a significant suppression of CD4+ T-cell proliferation in the presence of CD3/CD46-activated CD4+ T cells (n = 20). C, Inhibition of iNOS activity in Der p 2–activated primary nasal epithelial cells cultured with CD3/CD46-induced CD4+ T cells. D, A summary from 10 paired samples showed a significant difference between asthmatic patients after SIT. #P < .05 versus pre-SIT status. *P < .05 after treatment. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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