Presentation is loading. Please wait.

Presentation is loading. Please wait.

Nitric oxide and glomerulonephritis

Similar presentations


Presentation on theme: "Nitric oxide and glomerulonephritis"— Presentation transcript:

1 Nitric oxide and glomerulonephritis
Victoria Cattell  Kidney International  Volume 61, Issue 3, Pages (March 2002) DOI: /j x Copyright © 2002 International Society of Nephrology Terms and Conditions

2 Figure 1 Generation of nitrite (NO2-) by isolated glomeruli (gl) at intervals from 1 to 21 days after induction of accelerated nephrotoxic nephritis (ANTN). (A) Glomerular NO2- nm/2000 gl/48 h. The solid columns (▪) denote the macrophage (mø) numbers/gl. (B) Linear glomerular NO2- over a 48-hour incubation period. (C) Inhibition of glomerular NO2- by increasing concentrations of L-NMMA (0 to 50 μmol/L), reversed by 0.4mmol/L L-arginine. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions

3 Figure 2 Initial 24 hours after induction of heterologous nephrotoxic nephritis (HNTN). (A) Time course of leukocyte infiltration. Abbreviations are: mø, macrophages (dashed line); pmn, neutrophils (solid line). (B) Glomerular NO2- generation and iNOS mRNA induction. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions

4 Figure 3 Pattern of glomerular NO2- generation and histological changes in anti-Thy 1 GN. (a) Mesangiolysis, (b) aneurysm formation, (c) mesangial proliferation are shown. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions

5 Figure 4 Effects of N acetyl cysteine (NAC) in anti-Thy 1 GN. (A) Glomerular iNOS mRNA induction at two hours, RT-PCR doubling dilutions of template from 4 representative rats, 2 control and 2 NAC treated (B) glomerular NO2- generation [(▪) NAC-treated, (□) controls], (C) glomerular chemiluminescence (RLU = relative light units/600 gl) over one hour incubation period [(♦) NAC-treated, (•) controls]. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions

6 Figure 5 Summary of induction of nitric oxide (NO) synthesis and its potential roles in glomerulonephritis. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions


Download ppt "Nitric oxide and glomerulonephritis"

Similar presentations


Ads by Google