1. Hold the Door: Role of the Gut Barrier in Diabetes
Anthony Martin, Suzanne Devkota 
Cell Metabolism 
Volume 27, Issue 5, Pages (May 2018)
DOI: /j.cmet
Copyright © 2018 Elsevier Inc. Terms and Conditions

2. Figure 1
Hyperglycemia Disrupts Intestinal Epithelial Cell Barrier Integrity
Persistent vascular transport of glucose into intestinal epithelial cells via the insulin-independent GLUT2 transporter mediates aberrant intracellular glucose metabolism. This results in increased intestinal permeability, permissive translocation of bacterial products into systemic circulation, and sustained colonization of Citrobacter rodentium infection in the intestine. However, administration of insulin, genetic ablation of GLUT2, or inhibition of glucose metabolism with 2-deoxyglucose (2-DG) can reverse the consequential loss in barrier integrity and dissemination of bacterial products to systemic tissues.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2018 Elsevier Inc. Terms and Conditions