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Rajnish Mehrotra, Joel D. Kopple, Marsha Wolfson  Kidney International 

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Presentation on theme: "Rajnish Mehrotra, Joel D. Kopple, Marsha Wolfson  Kidney International "— Presentation transcript:

1 Metabolic acidosis in maintenance dialysis patients: Clinical considerations 
Rajnish Mehrotra, Joel D. Kopple, Marsha Wolfson  Kidney International  Volume 64, Pages S13-S25 (December 2003) DOI: /j x Copyright © 2003 International Society of Nephrology Terms and Conditions

2 Figure 1 The mechanisms by which metabolic acidosis may induce protein-energy malnutrition. Of the various pathways, the stimulation of the ATP-dependent ubiquitin-proteasome system by metabolic acidosis is the most well defined. Dotted lines indicate that the data supporting the role of these pathways are less well documented at this time. Kidney International  , S13-S25DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

3 Figure 2 The various mechanisms by which metabolic acidosis may contribute to bone disease. Dotted lines indicate that the data supporting the role of these pathways are less well documented at this time. Kidney International  , S13-S25DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions


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