1. Structural injuries and signs of cell death in fully differentiated Caco-2/TC7 clone cells infected with a Shiga toxin-positive E. coli strain.
Structural injuries and signs of cell death in fully differentiated Caco-2/TC7 clone cells infected with a Shiga toxin-positive E. coli strain. (A) Transmission electron microscopy micrograph of infected cells at an early time of infection, showing the loss of brush border and the opening of the junctional domain without a modification of the polarized organization of the cells forming a monolayer. (B) Transmission electron microscopy micrograph of infected cells at a late time of infection, showing the alteration of cell polarization, the disorganization of the apical domain, the detachment of cell debris, the appearance of a large disjunction at the junctional domain, and the cell detachment at the basal domain, indicating cell death.
Vanessa Liévin-Le Moal, and Alain L. Servin Microbiol. Mol. Biol. Rev. 2013; doi: /MMBR