1. * PXN VEGFA/B/C VEGFR2 SHC2 SRC CDC42 PLCG 1/2 SH2D2A PI3K MAPK14
miR-203; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-141/200a; miR-137; miR-1/206; miR-31; miR-144; miR-153; miR-214/761;miR-184; miR-208/208ab; miR-22; miR-499/499-5p; miR-182; miR-10; miR-503; miR-9; miR-138; miR-24; miR-204/211; miR-218
PXN
miR-200bc/429; miR-204/211; miR-135; miR-218; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-182; miR-101; miR-96/1271; miR-1/206; miR-125/351; miR-205; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-214/761; miR-129/129-5p; miR-155; miR-103/107; miR-455/455-5p; miR-223; miR-181
VEGFA/B/C
VEGFR2
SHC2
SRC
CDC42
PLCG
1/2
SH2D2A
PI3K
MAPK14
MAPKAPK2
HSPB2
FAK
CALN1
NFAT5
PKC
SPK
RAS
RAF1
MAP2K
MAPK1
KAT5
IP3
Ca2+
DAG
miR-200bc/429; miR-221/222; miR-455/455-5p; miR-138; miR-15/16/195/424/497; miR-338/338-3p; miR-23ab; miR-129/129-5p; miR-141/200a; miR-375; miR-214/761
VEGFA: miR-29abc; miR-15/16/195/424/497; miR-205;miR-200bc/429; miR-383; miR-140/140-5p/876-3p; miR-203; miR-199/199-5p; miR-503; miR-1/206; miR-17-5p/20/93.mr/106/519.d; miR-103/107; miR-106/302; miR-150; miR-24; miR-139-5p; miR-34a/34b-5p/34c/34c-5p/449/449abc/699
VEGFB: miR-140/140-5p/876-3p; miR-101; miR-27ab; miR-125/351; miR-128; miR-375
VEGFC: miR-128; miR-27ab; miR-133; miR-101
miR-29abc; miR-1/206; miR-18ab; miR-137; miR-25/32/92/92ab/363/367; miR-129/129-5p; miR-27ab; miR-141/200a; miR-200bc/429; miR-31; miR-128
miR-9; miR-338/338-3p; miR-218; miR-146
FAK: miR-135; miR-138; miR-106/302; miR-196ab; miR-7/7ab; miR-221/222; miR-551ab; miR-145; miR-17-5p/20/93.mr/106/519.d; miR-199/199-5p; miR-139-5p; miR-25/32/92/92ab/363/367; miR-23ab
Paxillin: miR-203; miR-145; miR-216/216b; miR-137; miR-199/199-5p; miR-132/212; miR-24; miR-27ab; miR-125/351; miR-140/140-5p/876-3p; miR-9; miR-218; miR-122; miR-128
miR-103/107; miR-24; miR-15/16/195/424/497 *
SPHK1: miR-124/506; miR-1/206
SPHK2: miR-153; miR-130/301; miR-338/338-3p; miR-1/206; miR-19; miR-25/32/92/92ab/363/367; miR-184; miR-137; miR-181; miR-451; miR-503; miR-383; miR-15/16/195/424/497; miR-31
KRAS: miR-181; miR-27ab; miR-143; miR-217; miR-96/1271; miR-132/212; miR-155; miR-193ab; miR-19; miR-365; miR-199/199-5p; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-141/200a; miR-216/216b; miR-1/206; miR-425/489; miR-129/129-5p; miR-214/761; miR-146; miR-383; miR-190; miR-204/211; miR-23ab; miR-15/16/195/424/497; miR-200bc/429; miR-216/216a; miR-125/351; miR-128; miR-101; miR-218; miR-31; miR-144; miR-7/7ab; miR-194; miR-142-3p; miR-490/490-3p
HRAS: miR-338/338-3p
miR-203; miR-106/302; miR-10; miR-148/152; miR-155; miR-19; miR-124/506; miR-132/212; miR-124/506; miR-122; miR-203; miR-143; miR-142-3p; miR-25/32/92/92ab/363/367; miR-33/33ab; miR-129/129-5p; miR-24
miR-7/7ab; miR-19; miR-15/16/195/424/497; miR-125/351; miR-135; miR-455/455-5p; miR-503; miR-139-5p; miR-150; miR-1/206; miR-143
MAP2K1: miR-181; miR-15/16/195/424/497; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-148/152; miR-144; miR-96/1271; miR-130/301; miR-203; miR-503; miR-139-5p; miR-23ab
MAP2K2: miR-503
miR-204/211; miR-128; miR-132/212; miR-23ab; miR-150; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-27ab; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-190; miR-214/761; miR-10; miR-187; miR-29abc; miR-216/216a; miR-15/16/195/424/497; miR-122; miR-9; miR-125/351
miR-129/129-5p; miR-137; miR-96/1271; miR-22; miR-34a/34b-5p/34c/34c-5p/449/449abc/699
CALN1: miR-143; miR-218; miR-25/32/92/92ab/363/367; miR-33/33ab; miR-138; miR-200bc/429; miR-153; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-130/301; miR-129/129-5p; miR-183; miR-191; miR-122; miR-214/761; miR-199/199-5p; miR-22; miR-137; miR-133; miR-128; miR-135; let-7/98; miR-144; miR-21/590-5p; miR-205; miR-155; miR-7/7ab; miR-187; miR-145; miR-19; miR-204/211; miR-106/302; miR-103/107; miR-223; miR-1/206; miR-150; miR-375; miR-193ab; miR-23ab; miR-217; miR-203; miR-125/351; miR-383; miR-182; miR-192/215; miR-216/216b; miR-499/499-5p; miR-208/208ab; miR-132/212; miR-17-5p/20/93.mr/106/519.d; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-15/16/195/424/497; miR-139-5p; miR-503; miR-338/338-3p; miR-216/216a; miR-9; miR-26ab/1297; miR-221/222
NFAT5: miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-17-5p/20/93.mr/106/519.d; miR-205; miR-181; miR-148/152; miR-217; miR-194; miR-1/206; miR-124/506; miR-21/590-5p; miR-33/33ab; miR-150; miR-146; miR-132/212; miR-29abc; miR-190; miR-15/16/195/424/497; miR-7/7ab; miR-216/216b; miR-25/32/92/92ab/363/367; miR-203; miR-365; miR-183; miR-103/107; miR-31; miR-143; miR-122; miR-27ab; miR-18ab; miR-140/140-5p/876-3p; miR-10; miR-24; miR-22; miR-128; miR-210; miR-221/222; miR-135; miR-155; miR-101; miR-133; miR-383; miR-139-5p; miR-153; miR-200bc/429; miR-216/216a; miR-129/129-5p; miR-138; miR-499/499-5p; miR-9; miR-204/211; miR-196ab; miR-192/215; miR-490/490-3p; miR-375; miR-338/338-3p; miR-141/200a
miR-33/33ab; miR-19; miR-124/506; miR-128; miR-23ab; miR-22; miR-125/351; miR-24; miR-27ab; miR-216/216b; miR-375; miR-143; miR-133; miR-146; miR-145; miR-141/200a; miR-214/761; miR-130/301; miR-10
miR-137; miR-31; miR-9; miR-24; miR-7/7ab; miR-425/489; miR-19; miR-183; miR-150; miR-22; miR-125/351; miR-96/1271; miR-182; miR-214/761
miR-214/761

2. * PRKCA: miR-205; miR-203; miR-199/199-5p; miR-23ab; miR-223; miR-219/219-5p; miR-139-5p; miR-17-5p/20/93.mr/106/519.d; miR-132/212; miR-150; miR-200bc/429;miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-129/129-5p; miR-216/216b; miR-375; miR-15/16/195/424/497; miR-216/216a; miR-22; miR-338/338-3p; miR-141/200a; miR-9; miR-24; miR-183; miR-1/206; miR-193ab; miR-210; miR-125/351; miR-214/761; miR-10; miR-503; miR-181; miR-122; miR-146; miR-138; miR-194; miR-204/211; miR-490/490-3p; miR-192/215; miR-217; miR-7/7ab
PRKCB1: miR-183; miR-129/129-5p; miR-203; miR-141/200a; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-194; miR-182; miR-26ab/1297; miR-106/302; let-7/98; miR-365; miR-184; miR-148/152; miR-33/33ab; miR-29abc; miR-7/7ab
PRKCD: miR-26ab/1297; miR-181; miR-129/129-5p; miR-490/490-3p; miR-218; miR-27ab; miR-15/16/195/424/497
PRKCG: miR-338/338-3p; miR-503; miR-140/140-5p/876-3p; miR-135; miR-1/206
PRKCE: miR-31; miR-96/1271; miR-129/129-5p; miR-216/216a; miR-101; miR-141/200a; miR-146; miR-205; miR-103/107; miR-1/206; miR-33/33ab; miR-182; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-143; miR-223; miR-10; miR-181; miR-383; miR-144; miR-23ab; miR-22; miR-21/590-5p; miR-132/212; miR-218; miR-216/216b; miR-25/32/92/92ab/363/367; miR-139-5p; miR-106/302; miR-125/351; miR-29abc; miR-19
PRKCH: miR-24; miR-205; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-216/216a; miR-204/211; miR-27ab; miR-17-5p/20/93.mr/106/519.d; miR-145; miR-383; miR-216/216b; miR-221/222; miR-200bc/429; miR-455/455-5p; miR-214/761
PRKCI: miR-203; miR-455/455-5p; miR-103/107; miR-219/219-5p; miR-146; miR-365; miR-10; miR-155; miR-183; miR-199/199-5p; miR-23ab; miR-141/200a;miR-204/211;miR-15/16/195/424/497;miR-129/129-5p;miR-24;miR-33/33ab;miR-200bc/429;miR-96/1271;miR-29abc;miR-1/206;miR-150;miR-490/490-3p;miR-217;miR-138;miR-18ab;miR-216/216a;miR-182;miR-181
PRKCQ: miR-26ab/1297; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-192/215; miR-25/32/92/92ab/363/367; miR-203; miR-183; miR-193ab; miR-221/222; miR-137; miR-31; miR-214/761; miR-383; miR-200bc/429
PRKCZ: miR-148/152; miR-15/16/195/424/497; miR-338/338-3p; miR-503
Supplemental Figure 3. Overview of VEGF signaling.
Summary of VEGF signaling and predicted miRNA interactions. miRNAs that were described to be downregulated in renal cell carcinoma are highlighted in green, while upregulated miRNAs are highlighted in red; all other potential interactions are highlighted in black. Target interactions were predicted with TargetScan 5.1. miRNAs presented in this figure are all highly conserved among vertebrates; for a list of other miRNAs see Supplement Table 4.