1. Long Noncoding RNAs and Hepatocellular Carcinoma
James F. Collins 
Gastroenterology 
Volume 148, Issue 2, Pages (February 2015)
DOI: /j.gastro
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2. Figure 1
Pathologic regulatory pathway. Long noncoding RNA (lncRNA)-UFC1 is increased in hepatocellular carcinoma (HCC) samples from patients (upper left). UFC1 promotes translocation of the β-catenin transcript bound to HuR from the nucleus into the cytosol. Here, the UFC1/β-catenin/HuR complex stabilizes the β-catenin mRNA, leading to increased translation and production of β-catenin protein. Increased protein levels promote nuclear translocation, assisted by UFC1, where transcription of β-catenin target genes is enhanced (eg, c-myc, cyclin D1). The c-myc and cyclin D1 proteins (and perhaps others) then presumably lead to progression through the cell cycle, increasing cell proliferation, and also inhibit apoptosis of HCC cells. The overall effect then is tumor (and disease) progression. There is evidence that, under normal circumstances, lncRNA-UFC1 expression can be attenuated by microRNA (miRNA)-34a. Expression of this miRNA, is however, suppressed during HCC, allowing high lncRNA-UFC1 expression.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2015 AGA Institute Terms and Conditions