Presentation is loading. Please wait.

Presentation is loading. Please wait.

Histological and mRNA analysis of the inflammatory cytokines in the vehicle‐ or etifoxine‐treated mice at onset of clinical symptoms.A–D.At day 10 p.i.,

Published byZofia Muszyńska Modified over 5 years ago

Similar presentations

Presentation on theme: "Histological and mRNA analysis of the inflammatory cytokines in the vehicle‐ or etifoxine‐treated mice at onset of clinical symptoms.A–D.At day 10 p.i.,"— Presentation transcript:

1 Histological and mRNA analysis of the inflammatory cytokines in the vehicle‐ or etifoxine‐treated mice at onset of clinical symptoms.A–D.At day 10 p.i., drug treated animals showed significant differences in MBP (A), TSPO (B), Iba1 (C) and CD4 staining (D). Histological and mRNA analysis of the inflammatory cytokines in the vehicle‐ or etifoxine‐treated mice at onset of clinical symptoms.A–D.At day 10 p.i., drug treated animals showed significant differences in MBP (A), TSPO (B), Iba1 (C) and CD4 staining (D). (A) Animals treated with etifoxine showed an increase in retention of percentage of MBP coverage (*p = 0.001). Etifoxine treated animals also exhibited a decrease in TSPO+ cells per mm2 (*p = 0.004) (B), along with less Iba1+ cells per mm2 (*p = 0.02) (C). (D) The vehicle group showed infiltration of CD4+ cells, while no CD4+ cells were seen in the drug treated group. Infiltrated CD4+ cells were positive for TSPO expression.E.The mRNA levels corroborated the CD4 histology. Along with the decrease in CD4 mRNA (*p = 0.01), there was a decrease in transcripts of the inflammatory cytokines interferon‐γ (IFN‐γ) (*p = 0.02) and interleukin 17 (IL‐17) (*p = 0.04) in animals treated with etifoxine. The p‐values were calculated by t‐test, n = 8/group. Daniel J. Daugherty et al. EMBO Mol Med. 2013;5: © as stated in the article, figure or figure legend

Download ppt "Histological and mRNA analysis of the inflammatory cytokines in the vehicle‐ or etifoxine‐treated mice at onset of clinical symptoms.A–D.At day 10 p.i.,"

Similar presentations

The expressions of H19 and Igf1r are significantly decreased in the eutopic endometrium of women with endometriosis compared to those without endometriosis.

The expressions of H19 and Igf1r are significantly decreased in the eutopic endometrium of women with endometriosis compared to those without endometriosis.
Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.

Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.
From: Effective Arrestin–Specific Immunotherapy of Experimental Autoimmune Uveitis with RTL: A Prospect for Treatment of Human Uveitis Trans. Vis. Sci.

From: Effective Arrestin–Specific Immunotherapy of Experimental Autoimmune Uveitis with RTL: A Prospect for Treatment of Human Uveitis Trans. Vis. Sci.
Reduction in immune cell infiltration after stab wound injury in CCR2−/− mice increases proliferation at the injury site Reduction in immune cell infiltration.

Reduction in immune cell infiltration after stab wound injury in CCR2−/− mice increases proliferation at the injury site Reduction in immune cell infiltration.
Loss of Hdac3 impairs Ar signaling in mouse prostate tissues and has no effect on apoptosis Loss of Hdac3 impairs Ar signaling in mouse prostate tissues.

Loss of Hdac3 impairs Ar signaling in mouse prostate tissues and has no effect on apoptosis Loss of Hdac3 impairs Ar signaling in mouse prostate tissues.
Reduced astrocyte proliferation results in increased immune cell infiltration into the injured GM Reduced astrocyte proliferation results in increased.

Reduced astrocyte proliferation results in increased immune cell infiltration into the injured GM Reduced astrocyte proliferation results in increased.
PLAUhigh Tregs exhibit higher potential in suppressing effector T cells and express higher levels of Treg‐important genes, but they express lower levels.

PLAUhigh Tregs exhibit higher potential in suppressing effector T cells and express higher levels of Treg‐important genes, but they express lower levels.
Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice.

Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice.
Immunohistochemical staining for fibrin in wounds from Plg+/+ and Plg−/− mice treated with galardin or vehicle 7 days after surgery. Immunohistochemical.

Immunohistochemical staining for fibrin in wounds from Plg+/+ and Plg−/− mice treated with galardin or vehicle 7 days after surgery. Immunohistochemical.
PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection Proportion.

PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection Proportion.
IFNα, but not IFNλ, treatment induces cytokine secretion from human immune cells IFNα, but not IFNλ, treatment induces cytokine secretion from human immune.

IFNα, but not IFNλ, treatment induces cytokine secretion from human immune cells IFNα, but not IFNλ, treatment induces cytokine secretion from human immune.
Treatment with p38γ/p38δ inhibitor shows antifungal effects in vivo

Treatment with p38γ/p38δ inhibitor shows antifungal effects in vivo
AAV8‐hAAT‐FGF21 treatment improves liver fibrosis

AAV8‐hAAT‐FGF21 treatment improves liver fibrosis
TGF‐β1 and Sema3A are downregulated in vivo by increasing VEGF doses Muscles were harvested 7 days after implantation of V Low, V Med, and V High clones.

TGF‐β1 and Sema3A are downregulated in vivo by increasing VEGF doses Muscles were harvested 7 days after implantation of V Low, V Med, and V High clones.
Increased astrocyte proliferation is paralleled with reduced infiltration of immune cells in mice with inducible SMOM2 expression in astrocytes at 5 dpi.

Increased astrocyte proliferation is paralleled with reduced infiltration of immune cells in mice with inducible SMOM2 expression in astrocytes at 5 dpi.
Clinical testing of calcineurin inhibitors cyclosporine A and tacrolimus in autoimmune disorders Clinical testing of calcineurin inhibitors cyclosporine.

Clinical testing of calcineurin inhibitors cyclosporine A and tacrolimus in autoimmune disorders Clinical testing of calcineurin inhibitors cyclosporine.
No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO Cre+ mice No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO.

No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO Cre+ mice No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO.
Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),

Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),
Inhibition of JNK signaling in breast cancer cells and lung colonization in a xenograft mouse model Inhibition of JNK signaling in breast cancer cells.

Inhibition of JNK signaling in breast cancer cells and lung colonization in a xenograft mouse model Inhibition of JNK signaling in breast cancer cells.
SKAP55‐deficient mice enhance DC‐based vaccine for prevention of tumors in vivo AWT and SKAP55 KO C57BL/6 mice were s.c. immunized on day −14 and day −7.

SKAP55‐deficient mice enhance DC‐based vaccine for prevention of tumors in vivo AWT and SKAP55 KO C57BL/6 mice were s.c. immunized on day −14 and day −7.

Similar presentations

Ads by Google