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Difference in acetylcholine-induced nitric oxide release of arterial and venous grafts in patients after coronary bypass operations  Hiroaki Nishioka,

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Presentation on theme: "Difference in acetylcholine-induced nitric oxide release of arterial and venous grafts in patients after coronary bypass operations  Hiroaki Nishioka,"— Presentation transcript:

1 Difference in acetylcholine-induced nitric oxide release of arterial and venous grafts in patients after coronary bypass operations  Hiroaki Nishioka, MD, Soichiro Kitamura, MD, Yoichi Kameda, MD, Shigeki Taniguchi, MD, Tetsuji Kawata, MD, Kazumi Mizuguchi, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 116, Issue 3, Pages (September 1998) DOI: /S (98)70011-X Copyright © 1998 Mosby, Inc. Terms and Conditions

2 Fig. 1 Plasma NO2– concentration after stimulation with acetylcholine compared with control level for grafts bypassed to the LCX. For grafts to the LCX, plasma NO2– concentration after stimulation with acetylcholine compared with the control value was significantly higher in ITA grafts than in SVGs at 4 minutes (p = 0.04) and at 6 minutes (p = 0.01). This response was similar to the result for all study grafts, including grafts to other coronary arteries. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (98)70011-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

3 Fig. 2 The relation between the change in nitrite level after acetylcholine infusion and the graft age (period between graft implantation and the study). There was no significant correlation by regression analysis between the change of plasma NO2– level after acetylcholine infusion and the graft age. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (98)70011-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

4 Fig. 3 Angiograms of an SVG implanted to the LCX in a 65-year-old man taken 115 months after the operation in the control condition (left) and after intragraft infusion of 5 μg acetylcholine (right). The native coronary artery bypassed with an SVG constricted after acetylcholine administration. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (98)70011-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

5 Fig. 4 Angiograms of a left ITA graft implanted to the left anterior descending artery in a 52-year-old man taken 145 months after the operation in the control condition (left) and after intragraft infusion of 5 μg acetylcholine (right). The native coronary artery bypassed with an ITA graft dilated after acetylcholine administration. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (98)70011-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

6 Fig. 5 Vasomotor responses of the grafts to acetylcholine (ACH) infusion. Low-dose acetylcholine dilated ITA grafts whereas the SVGs were reduced in diameter (ITA vs SVG, p = 0.02). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (98)70011-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

7 Fig. 6 Vasomotor responses of the grafted coronary arteries to acetylcholine (ACH) infusion. Acetylcholine-induced vasoconstriction was significantly less in the coronary arteries grafted with ITA grafts than in those grafted with SVGs (p = 0.01). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (98)70011-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

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