2. Inflammatory Bowel Disease (IBD)
Bowel Cancer
Inflammatory Bowel Disease (IBD)
Other Bowel Disorders
Anal cancer
Colon cancer
Rectal cancer
Crohn’s disease
Ulcerative colitis
Diverticulitis
Irritable bowel syndrome
Fistula
Rectal prolapse
Bowel obstruction
Incontinence
+ many others…..

3. BDRF Research Strategic Framework
Understanding the causes and mechanisms of disease
Cause 
Learning how to combat the disease at its source 
Primary – preventing a precursor of the disease
Prevention
Research Pathways 
Secondary – applying a test to diagnose through screening methods 
Adjuvant therapies and drug treatment
Treatment 
Surgical procedures 
Living with disease
Containment
Ensuring best quality of life – mental, physical, social, aspects 
Cure 
Ultimate eradication

4. Cause Crohn’s Prevention Bowel Cancer Treatment Containment Colitis
Genetics – familial adenomatous polyposis FAP , hereditary non-polyposis colorectal cancer syndrome (HNPCC) or Lynch syndrome 
Cause
Environmental factors – diet, social & economic, alcohol, Inflammatory Bowel Disease
Crohn’s  
Primary – genetic monitoring, dietary factors, aspirin
Prevention
Bowel Cancer 
Secondary – faecal occult blood test (FOBt) Colonoscopy, MRI, ultrasound 
Pre-disease, early disease, later disease, late disease – TNM staging
Treatment 
Surgical procedures, radiotherapy, chemotherapy 
Living with disease
Containment
Ensuring best quality of life – mental, physical, social, aspects 
Colitis
Cure 
Removal of tumor, section of bowel , possibility of a stoma

5. Inflammatory Bowel Disease
Genetics – having a close relative with the condition 
Cause
Crohn’s 
Disruption to or malfunction of to the immune system 
Primary – genetic monitoring, dietary factors, smoking, geographic factors
Prevention
Inflammatory Bowel Disease 
Secondary – blood tests, endoscopic techniques, imaging 
Treatment
Reducing the effects of the inflammation through drugs or surgery 
Developing clear treatments pathways, joined up care , top down and step up methodology 
Reducing the side effects of treatments. Living with a stoma
Containment 
Ensuring best quality of life – mental, physical, social, aspects
Cure 
There is currently no cure

6. Cause Prevention Bowel Disorders Treatment Containment Cure 
Pregnancy, injury to sphincter muscles , dietary factors
Cause 
Age – elderly and the young, neurological conditions 
Improving obstetric care
Bowel Disorders
Prevention 
Lifestyle and dietary 
Drug treatment, innovative less invasive treatments
Treatment 
Surgical procedures 
Living with the disorder but reducing its effects
Containment 
Ensuring best quality of life – mental, physical, social, aspects
Cure 
Ultimate eradication