1. A role for niches in the development of a multiplicity of dendritic cell subsets 
Geneviève Despars, Helen C O'Neill 
Experimental Hematology 
Volume 32, Issue 3, Pages (March 2004)
DOI: /j.exphem

2. Figure 1
A model for DC hematopoiesis dependent on tissue-specific niches. Comparison is made between normal steady-state development or homeostasis (A) and the contribution of abnormal niches to autoimmune diseases. (B) Either hematopoietic stem cells (HSC) or committed DC progenitor cells circulating in blood lodge in tissue niches and self-renew in contact with stromal cells. Signaling events between progenitors and stromal cells lead to cell-fate decisions and the production of DC progenitors. In some sites progenitors resemble the common lymphoid progenitor (CLP) or the common myeloid progenitor (CMP) described in bone marrow. In other sites, the nature of any progenitor is unknown. The model predicts that DC precursors can develop into different subsets of DC in situ, including the plasmacytoid DC (p-DC), Langerhans cells (LC), the subsets of CD8α+ and CD8α− myeloid DC, and the thymic CD205+ CD8α+ lymphoid-like DC. The impact of abnormal niches on the development of autoimmune disease is illustrated via the production of dysfunctional DC that interfere with the normal processes of lymphocyte development and tolerance induction.
Experimental Hematology  , DOI: ( /j.exphem )