1. Unexpected Autocrine Role of Vascular Endothelial Growth Factor in Squamous Cell Carcinoma 
Jack L. Arbiser 
Journal of Investigative Dermatology 
Volume 129, Issue 3, Pages (March 2009)
DOI: /jid
Copyright © 2009 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Blockade of autocrine VEGF signaling in keratinocytes leads to a serum-deprived phenotype in squamous cell carcinoma. Impaired tyrosine kinase signaling due to lack of VEGF or other growth factors may lead to increased dependence on other oncogenic factors, e.g. mutated ras. Ras activation in the presence of serum deprivation leads to survival based upon activation of phospholipase D–mediated generation of phosphatidic acid.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2009 The Society for Investigative Dermatology, Inc Terms and Conditions