1. Safety and immunogenicity of a live attenuated influenza H5 candidate vaccine strain A/17/turkey/Turkey/05/133 H5N2 and its priming effects for potential pre-pandemic use: a randomised, double-blind, placebo-controlled trial 
Prof Punnee Pitisuttithum, MD, Kobporn Boonnak, PhD, Supat Chamnanchanunt, MD, Prof Pilaipan Puthavathana, PhD, Viravarn Luvira, MD, Hatairat Lerdsamran, PhD, Jaranit Kaewkungwal, PhD, Saranath Lawpoolsri, MD, Vipa Thanachartwet, MD, Udomsak Silachamroon, MD, Wanibtisam Masamae, MSc, Alexandra Schuetz, PhD, Ponthip Wirachwong, PhD, Sit Thirapakpoomanunt, BPharm, Larisa Rudenko, MD, Erin Sparrow, MSc, Martin Friede, PhD, Marie-Paule Kieny, PhD 
The Lancet Infectious Diseases 
Volume 17, Issue 8, Pages (August 2017)
DOI: /S (17)
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2. Figure 1
Trial profile
Overview of participants who received LAIV H5N2 vaccine or placebo (A) and those who subsequently received H5N1 inactivated influenza vaccine (B). HAI=haemagglutination inhibition. ITT=intention-to-treat. LAIV H5N2=H5N2 live attenuated influenza vaccine. *Participants who had received at least one dose of LAIV H5N2 vaccine (n=51) were included in ITT analysis for safety. †Participants who had received two doses of LAIV H5N2 vaccine (n=49) were included in ITT analysis for immune response. ‡Humoral responses in two participants were obtained only on day 1 (before vaccination): one withdrawn by physician; one did not provide blood sample for analysis. §Humoral response in one participant was obtained only on day 1 (before vaccination); participant voluntarily withdrew. ¶One participant withdrawn by physician, one lost to follow-up. ||Two participants did not receive second immunisation; one voluntarily withdrew.
The Lancet Infectious Diseases  , DOI: ( /S (17) )
Copyright © 2017 World Health Organization Terms and Conditions

3. Figure 2
Follicular T-helper cells (A) and plasmablast cells (B) in circulating blood in participants who received inactivated H5N1 vaccine boost
Follicular T-helper cells were defined as ICOS+CXCR3+CXCR5+CD4+ cells. Plasmablast cells were defined as CD19+CD3–CD20loCD27+CD38+ cells.
The Lancet Infectious Diseases  , DOI: ( /S (17) )
Copyright © 2017 World Health Organization Terms and Conditions