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Use of deep laryngeal oxygen insufflation during laryngoscopy in children: a randomized clinical trial  J.W. Steiner, D.I. Sessler, N. Makarova, E.J.

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Presentation on theme: "Use of deep laryngeal oxygen insufflation during laryngoscopy in children: a randomized clinical trial  J.W. Steiner, D.I. Sessler, N. Makarova, E.J."— Presentation transcript:

1 Use of deep laryngeal oxygen insufflation during laryngoscopy in children: a randomized clinical trial  J.W. Steiner, D.I. Sessler, N. Makarova, E.J. Mascha, P.N. Olomu, J.W. Zhong, C.T. Setiawan, A.E. Handy, B.N. Kravitz, P. Szmuk  British Journal of Anaesthesia  Volume 117, Issue 3, Pages (September 2016) DOI: /bja/aew186 Copyright © 2016 The Author(s) Terms and Conditions

2 Fig 1 Consort flow diagram.
British Journal of Anaesthesia  , DOI: ( /bja/aew186) Copyright © 2016 The Author(s) Terms and Conditions

3 Fig 2 Interim monitoring results for efficacy and futility. Group sequential design plot shows the observed Z statistic across the interim analyses. By n=263, both Truview PCD laryngoscope (VLO2) and direct laryngoscopy with cannula (DLO2) comparisons with DL had crossed the efficacy (i.e. superiority) boundary for each primary outcome (time to 1% reduction in saturation and overall desaturation rate). The study continued to obtain more precise estimates of the treatment effects. British Journal of Anaesthesia  , DOI: ( /bja/aew186) Copyright © 2016 The Author(s) Terms and Conditions

4 Fig 3 Joint hypothesis testing primary outcome results. Both Truview PCD laryngoscope (VLO2) and direct laryngoscopy with cannula (DLO2) groups were found to be superior to direct laryngoscopy alone (DL); both groups were superior on the time to 1% reduction in saturation from the baseline and on overall rate of desaturation. British Journal of Anaesthesia  , DOI: ( /bja/aew186) Copyright © 2016 The Author(s) Terms and Conditions

5 Fig 4 Kaplan–Meier curves of time to 1% reduction in saturation from the baseline. Time to 1% reduction in saturation was censored at the end of intubation. British Journal of Anaesthesia  , DOI: ( /bja/aew186) Copyright © 2016 The Author(s) Terms and Conditions


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