Presentation is loading. Please wait.

Presentation is loading. Please wait.

Contribution of tubular injury to loss of remnant kidney function

Similar presentations


Presentation on theme: "Contribution of tubular injury to loss of remnant kidney function"— Presentation transcript:

1 Contribution of tubular injury to loss of remnant kidney function
Mehul Gandhi, Jean L. Olson, Timothy W. Meyer  Kidney International  Volume 54, Issue 4, Pages (October 1998) DOI: /j x Copyright © 1998 International Society of Nephrology Terms and Conditions

2 Figure 1 Sections of kidney cortex from the three groups. (A) Normal kidney structure in a control rat. (B) Moderate tubulointerstitial injury and segmental glomerular sclerosis in a REM 10 rat examined at 10weeks after ablation. (C) More advanced tubulointerstitial injury and glomerular sclerosis in a REM 25 rat examined at 25weeks after ablation. Serial sections showed that many glomeruli were no longer connected to proximal tubules (Toluidine blue, magnification ×50). Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

3 Figure 1 Sections of kidney cortex from the three groups. (A) Normal kidney structure in a control rat. (B) Moderate tubulointerstitial injury and segmental glomerular sclerosis in a REM 10 rat examined at 10weeks after ablation. (C) More advanced tubulointerstitial injury and glomerular sclerosis in a REM 25 rat examined at 25weeks after ablation. Serial sections showed that many glomeruli were no longer connected to proximal tubules (Toluidine blue, magnification ×50). Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

4 Figure 2 Alterations in the glomerulus and glomerular-tubular junction at 25weeks after ablation. (A) Midsection of an atubular glomerulus with open capillary loops and relatively little sclerotic injury. (B) This glomerulus was attached to an atrophic tubule (arrow) but also showed relatively little sclerotic injury. (C) In contrast, sclerotic injury was more severe in this glomerulus, which remained attached to a normal proximal tubule (arrows) (Toluidine blue, magnification ×400). Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

5 Figure 2 Alterations in the glomerulus and glomerular-tubular junction at 25weeks after ablation. (A) Midsection of an atubular glomerulus with open capillary loops and relatively little sclerotic injury. (B) This glomerulus was attached to an atrophic tubule (arrow) but also showed relatively little sclerotic injury. (C) In contrast, sclerotic injury was more severe in this glomerulus, which remained attached to a normal proximal tubule (arrows) (Toluidine blue, magnification ×400). Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

6 Kidney International 1998 54, 1157-1165DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

7 Kidney International 1998 54, 1157-1165DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

8 Kidney International 1998 54, 1157-1165DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

9 Kidney International 1998 54, 1157-1165DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

10 Kidney International 1998 54, 1157-1165DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions


Download ppt "Contribution of tubular injury to loss of remnant kidney function"

Similar presentations


Ads by Google