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Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen.

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Presentation on theme: "Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen."— Presentation transcript:

1 Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown  Changhai Ding, M.D., Patrick Garnero, Ph.D., Flavia Cicuttini, Ph.D., Fiona Scott, M.B.B.S., Helen Cooley, M.D., Graeme Jones, M.D.  Osteoarthritis and Cartilage  Volume 13, Issue 3, Pages (March 2005) DOI: /j.joca Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

2 Fig. 1 Sagittal T1-weighted fat saturated 3D MRI images shows: (A) Normal lateral tibial, lateral femoral and patellar cartilage (grade 0). (B) Slight cartilage defects at lateral tibial and patellar site (grade 1) but moderate cartilage defects at lateral femoral site (grade 2). (C) Normal cartilage at patellar site (grade 0) but severe cartilage defects at lateral tibial and femoral sites (grade 3). (D) Severe cartilage defects at medial tibial (grade 4) and femoral (grade 3) sites. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

3 Fig. 2 Correlation between knee cartilage defects and U-CTX-II. There were significant positive associations between CTX-II and knee cartilage defect severity in all compartments in total sample and women, but not men. T: total sample; F: females; M: males. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

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