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Growth factors improve latissimus dorsi muscle vascularization and trophicity after cardiomyoplasty  Gilbert Zakine, MD, Emmanuel Martinod, MD, Paul Fornes,

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Presentation on theme: "Growth factors improve latissimus dorsi muscle vascularization and trophicity after cardiomyoplasty  Gilbert Zakine, MD, Emmanuel Martinod, MD, Paul Fornes,"— Presentation transcript:

1 Growth factors improve latissimus dorsi muscle vascularization and trophicity after cardiomyoplasty 
Gilbert Zakine, MD, Emmanuel Martinod, MD, Paul Fornes, MD, Marc Sapoval, MD, Denis Barritault, PhD, Alain F Carpentier, MD, PhD, Juan Carlos Chachques, MD, PhD  The Annals of Thoracic Surgery  Volume 75, Issue 2, Pages (February 2003) DOI: /S (02)

2 Fig 1 The growth factors delivery catheter was placed between the epicardium and the latissimus dorsi muscle. A sensing epicardial electrode was inserted in the left ventricular wall. The Annals of Thoracic Surgery  , DOI: ( /S (02) )

3 Fig 2 Angiographic studies. (A) Control group. (B) Basic fibroblast growth factor group showing hypervascularization of thoracodorsal artery branches and helical arteries (neoangiogenesis). (Arrows show helical arteries.) The Annals of Thoracic Surgery  , DOI: ( /S (02) )

4 Fig 3 Histologic studies. (A) Control group showing atrophy in the distal portion of the latissimus dorsi muscle (LDM) (hematoxylin-eosin-saffron, magnification ×40). (∣ = the borderline between the epicardium and the LDM.) (B) Basic fibroblast growth factor (bFGF) group showing a preserved LDM trophicity (hematoxylin-eosin-saffron, magnification ×20). (C) bFGF group. A large number of neocapillaries (arrows) is observed between the LDM fibers (hematoxylin-eosin-saffron, magnification ×400). The Annals of Thoracic Surgery  , DOI: ( /S (02) )

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