Presentation is loading. Please wait.

Presentation is loading. Please wait.

Fig. 5 HDAC inhibition blocks age-dependent diastolic dysfunction.

Published byRussell Matthews Modified over 5 years ago

Similar presentations

Presentation on theme: "Fig. 5 HDAC inhibition blocks age-dependent diastolic dysfunction."— Presentation transcript:

1 Fig. 5 HDAC inhibition blocks age-dependent diastolic dysfunction.
HDAC inhibition blocks age-dependent diastolic dysfunction. (A) Study overview. Nine-month-old female 129S6/SvEvTac mice were fed normal chow or chow containing ITF2357 (50 mg/kg) for 11 months. Serial echocardiography was performed at 9, 15, 17, and 20 months. (B) Doppler measurement of mitral inflow velocity (E/A) in aged mice treated with vehicle or HDAC inhibitor. Measurements of septal mitral annulus velocities (E′/A′) (C) and IVRT (D). Mouse numbers for each time point are provided in table S7. Mean systemic blood pressure (MSP) (E) and LV-to-tibia length (F) in 20-month-old mice treated with or without ITF2357. (G to J) Ex vivo mechanics analyses of myofibrils from 20-month-old mice fed normal chow or ITF2357-containing chow. Data are mean + SEM and were compared by Student’s t test. *P < 0.05 versus untreated controls. n = 4 mice per group; 9 to 10 myofibril bundles were analyzed per animal. Mark Y. Jeong et al., Sci Transl Med 2018;10:eaao0144 Published by AAAS

Download ppt "Fig. 5 HDAC inhibition blocks age-dependent diastolic dysfunction."

Similar presentations

A B Figure S1. Macroscopic analyses of the ColIITgcog mouse phenotype (female mice) (A) Graph and table of body weights and percentage differences of female.

A B Figure S1. Macroscopic analyses of the ColIITgcog mouse phenotype (female mice) (A) Graph and table of body weights and percentage differences of female.
Fig. 1 CSF1 is increased in blood of melanoma patients and correlates with disease progression. CSF1 is increased in blood of melanoma patients and correlates.

Fig. 1 CSF1 is increased in blood of melanoma patients and correlates with disease progression. CSF1 is increased in blood of melanoma patients and correlates.
Fig. 6. Transgenic expression of αLNNd and mag in dyW/dyW mice improves muscle function, increases body weight, and prolongs life span. Transgenic expression.

Fig. 6. Transgenic expression of αLNNd and mag in dyW/dyW mice improves muscle function, increases body weight, and prolongs life span. Transgenic expression.
Pitx2 haploinsufficiency rescues Tbx5 haploinsufficiency in mice

Pitx2 haploinsufficiency rescues Tbx5 haploinsufficiency in mice
Fig. 6. AZD6738 induces DNA damage and apoptosis and exhibits antitumor efficacy in xenograft models of high-risk medulloblastoma and neuroblastoma. AZD6738.

Fig. 6. AZD6738 induces DNA damage and apoptosis and exhibits antitumor efficacy in xenograft models of high-risk medulloblastoma and neuroblastoma. AZD6738.
Fig. 5. Blocking LTB4 during initial lymphangiogenesis period abrogates the therapeutic benefit of LTB4 antagonism. Blocking LTB4 during initial lymphangiogenesis.

Fig. 5. Blocking LTB4 during initial lymphangiogenesis period abrogates the therapeutic benefit of LTB4 antagonism. Blocking LTB4 during initial lymphangiogenesis.
Figure 2 Echocardiographic methods to estimate left atrial pressure

Figure 2 Echocardiographic methods to estimate left atrial pressure
Muaz M. Abudiab et al. JIMG 2017;j.jcmg

Muaz M. Abudiab et al. JIMG 2017;j.jcmg
Transfer of miR-223 during neutrophil-epithelial cell interactions

Transfer of miR-223 during neutrophil-epithelial cell interactions
Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.
Fig. 4. Bexarotene promotes PPARδ activation of target genes in mouse brain and muscle. Bexarotene promotes PPARδ activation of target genes in mouse brain.

Fig. 4. Bexarotene promotes PPARδ activation of target genes in mouse brain and muscle. Bexarotene promotes PPARδ activation of target genes in mouse brain.
Fig. 5. Correlation of tail and long bone growth velocities with Cxm serum concentrations in mice. Correlation of tail and long bone growth velocities.

Fig. 5. Correlation of tail and long bone growth velocities with Cxm serum concentrations in mice. Correlation of tail and long bone growth velocities.
Fig. 1. Ketoprofen efficacy in a preclinical model of lymphedema can be attributed to its inhibition of LTB4. Ketoprofen efficacy in a preclinical model.

Fig. 1. Ketoprofen efficacy in a preclinical model of lymphedema can be attributed to its inhibition of LTB4. Ketoprofen efficacy in a preclinical model.
Fig. 5 Maraba induces antitumor T cell immunity.

Fig. 5 Maraba induces antitumor T cell immunity.
In vivo prophylactic and therapeutic efficacy of C12G6 in mice

In vivo prophylactic and therapeutic efficacy of C12G6 in mice
Fig. 4. Biomechanical properties of treated tibiae.

Fig. 4. Biomechanical properties of treated tibiae.
Fig. 6. Treatment with a DLK inhibitor is neuroprotective and reverses stress-induced gene expression changes. Treatment with a DLK inhibitor is neuroprotective.

Fig. 6. Treatment with a DLK inhibitor is neuroprotective and reverses stress-induced gene expression changes. Treatment with a DLK inhibitor is neuroprotective.
Fig. 8. In vivo suppression of MM by CMLD

Fig. 8. In vivo suppression of MM by CMLD
Echocardiography findings in HFNEF

Echocardiography findings in HFNEF
Fig. 2 Maraba treatment results in complete responses in the window of opportunity setting. Maraba treatment results in complete responses in the window.

Fig. 2 Maraba treatment results in complete responses in the window of opportunity setting. Maraba treatment results in complete responses in the window.

Similar presentations

Ads by Google