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Measurement of heparin concentration in whole blood with the Hepcon/HMS device does not agree with laboratory determination of plasma heparin concentration.

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Presentation on theme: "Measurement of heparin concentration in whole blood with the Hepcon/HMS device does not agree with laboratory determination of plasma heparin concentration."— Presentation transcript:

1 Measurement of heparin concentration in whole blood with the Hepcon/HMS device does not agree with laboratory determination of plasma heparin concentration using a chromogenic substrate for activated factor X  Jean-François Hardy, MD, FRCPC, Sylvain Bélisle, MD, FRCPC, Danielle Robitaille, MD, FRCPC, Jean Perrault, PhD, Micheline Roy, RT, Line Gagnon, RT  The Journal of Thoracic and Cardiovascular Surgery  Volume 112, Issue 1, Pages (July 1996) DOI: /S (96) Copyright © 1996 Mosby, Inc. Terms and Conditions

2 Fig. 1 Bland-Altman plot in view of determining agreement between laboratory anti-Xa determination of plasma heparin concentration (plasma [Hep]) and whole blood determination of heparin concentration (whole blood [Hep]) with the Hepcon/HMS instrument. The shaded area shows the predetermined limits of agreement (±0.7 U/ml, see text for details). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

3 Fig. 2 Mean difference (black circles) ±2 standard deviations (arrows) of the differences between laboratory anti-Xa determination of plasma heparin concentration (plasma [Hep]) and whole blood determination of heparin concentration with the Hepcon/HMS instrument (whole blood [Hep]) at different time intervals during the operation. Ao, Aortic. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

4 Fig. 3 Correlation between laboratory anti-Xa determination of plasma heparin concentration (plasma [Hep]) and plasma equivalent heparin concentration calculated from hematocrit value and whole blood determination of heparin concentration with the Hepcon/HMS instrument (plasma equivalent [Hep]). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

5 Fig. 4 Mean difference (black circles) ±2 standard deviations (arrows) of the differences between laboratory anti-Xa determination of plasma heparin concentration (plasma [Hep]) and plasma equivalent heparin concentration calculated from hematocrit value and whole blood determination of heparin concentration with the Hepcon/HMS instrument (plasma equivalent [Hep]). Ao, Aortic. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

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