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Intercepting Cancer Communiques: Exosomes as Heralds of Malignancy

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1 Intercepting Cancer Communiques: Exosomes as Heralds of Malignancy
Sunil R. Hingorani  Cancer Cell  Volume 28, Issue 2, Pages (August 2015) DOI: /j.ccell Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 GPC1 Marks Pancreas Cancer Exosomes
(A) Exosomes are formed by intraluminal budding as early endosomes (EE) mature into multivesicular bodies (MVB). When MVB fuse with the plasma membrane (PM), exosomes are secreted into the microenvironment and can enter the bloodstream. GPC1 is a heparan sulfate (hs) proteoglycan tethered to the surface of cells and exosomes through a specific glycophosphatidyl linkage (yellow). (B) Melo et al. (2015) report that GPC1+ circulating exosomes are frequent in the sera of patients with preinvasive and invasive pancreas cancer but rare in healthy patients and those with benign pancreatic disease (BPD). Cancer Cell  , DOI: ( /j.ccell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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