1. Metabolic Regulation by p53 Family Members
Celia R. Berkers, Oliver D.K. Maddocks, Eric C. Cheung, Inbal Mor, Karen H. Vousden 
Cell Metabolism 
Volume 18, Issue 5, Pages (November 2013)
DOI: /j.cmet
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2. Figure 1
Outline of the Interaction between p53 Family Members and Metabolic Pathways
p53 and its family members p63 and p73 have been implicated in many aspects of cellular metabolism, including AMPK and mTOR signalling, carbohydrate and lipid metabolism, the regulation of autophagy, and the maintenance of mitochondrial integrity and REDOX balance.
Cell Metabolism  , DOI: ( /j.cmet )
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3. Figure 2
Outline of the Crosstalk between p53 Family Members and the mTORC1 Pathway
p53 and p63 act upstream of mTORC1 and inhibit mTORC1 activity via multiple transcriptional targets. p53, p63, and p73 can all be modulated by the AMPK/mTORC1 pathway (indicated in red and blue, respectively) and link mTORC1 signalling to multiple downstream effects, including, but not limited to, cell-cycle control (via p53), autophagy (via p73), and differentiation (via p63).
Cell Metabolism  , DOI: ( /j.cmet )
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4. Figure 3
Outline of the Regulation of Central Carbohydrate Metabolism by p53
p53 generally dampens aerobic glycolysis (blue) and promotes mitochondrial respiration (green) through multiple mechanisms, although it can both positively and negatively modulate PPP activity.
Cell Metabolism  , DOI: ( /j.cmet )
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5. Figure 4 Outline of the Regulation of Lipid Metabolism by p53
p53 generally functions as a negative regulator of lipid synthesis by enhancing fatty acid oxidation (red) and inhibiting fatty acid synthesis (blue) through multiple mechanisms.
Cell Metabolism  , DOI: ( /j.cmet )
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