1. Self-assembly in Nature

2. Nano

3. Self-assembly of amphiphilic molecules

4. spherical micelles
cylindrical
micelles
nanotubes
vesicles (liposomes)

6. Drug delivery systems
Direct conjugation of drugs or therapeutic proteins
to macromolecules such as polymers and proteins.

7. 2. Encapsulation of hydrophobic drugs at the inside of the micelles or dendrimers

8. 3. Entrapment of water-soluble drugs at the inside cavity of vesicles

9. The enhanced permeability and retention (EPR) effect
Macromolecules cannot pass through the capillary walls of normal tissue. The entry of macromolecules into tumor tissue takes place in the capillaries where blood flow is diminished and nutrients transfer into the tissue. In contrast to the blood capillaries in most normal tissues, the endothelial layer of the capillaries in the tumor tissue is fenestrated and leaky so that macromolecules and other nanoparticles reach the malignant tissue. Tumor tissue generally has a defective lymphatic drainage system with the result that macromolecules are retained and can subsequently accumulate in solid tumors.

11. pH-Responsive Nanocapsules1 10
100
3nm
18nm
Radius (nm)
DLS
pH 7
pH 5
HCl
pH drop
Vesicle
d = 36 nm
Micelle
d = 6 nm
pH 7
pH 5
Release of Calcein
J. Am. Chem. Soc. 2004, 126, 12724

12. 암세포에만 약물을 방출하는 나노 운반체

14. Carbohydrate – Protein Multivalent Interactions
Antigen
antigen
carbohydrate
Kiessling et. al. J. Am. Chem. Soc. 2002, 124,

15. Mannose-Coated Supramolecules
n.d.
glycocluster
lectin protein
Hemagglutination Inhibition Assay
Vesicle
Sphere
Cylinder
Galactose
Micelle 12 1 23 2 3
50 nm
d= 40 nm
100 nm
d= 20 nm
d= 10 nm
J. Am. Chem. Soc. 2005, 127, 16333
Chem. Commun. 2005, 2035
J. Am. Chem. Soc. 2007, in press

16. E. Coli (ORN 178) + cylinders
Selective Binding of Supramolecules to Bacterial Cells
TEM
Binding to
E. coli ORN 178
pili
E. coli
E. Coli (ORN 178) + spheres
100 nm
E. Coli (ORN 178) + cylinders
E. Coli (ORN 208)

17. + Binding of Bacterial Cells = Selective-binding Pathogen
ß-sheet assembly =
D-mannose-binding protein
Selective-binding