1. Statins: Old drugs as new therapy for liver diseases?
Elisa Pose, Jonel Trebicka, Rajeshwar P Mookerjee, Paolo Angeli, Pere Ginès 
Journal of Hepatology 
Volume 70, Issue 1, Pages (January 2019)
DOI: /j.jhep
Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

2. Fig. 1
Pleiotropic effects of statins on small GTPases in the liver. The decrease in activation of small GPTases RhoA and Ras in hepatic stellate cells and liver sinusoidal endothelial cells leads to changes in the subsequent signalling pathways, which results in less fibrogenesis, less hepatic inflammation and lower portal pressure. Additional statins have direct effects on hepatocyte growth and proliferation signals and thereby might abrogate the development of hepatocellular carcinoma.
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2018 European Association for the Study of the Liver Terms and Conditions