Presentation is loading. Please wait.

Presentation is loading. Please wait.

ZMP: A Master Regulator of One-Carbon Metabolism

Published byΖώνα Μιχαηλίδης Modified over 5 years ago

Similar presentations

Presentation on theme: "ZMP: A Master Regulator of One-Carbon Metabolism"— Presentation transcript:

1 ZMP: A Master Regulator of One-Carbon Metabolism
Gregory S. Ducker, Joshua D. Rabinowitz  Molecular Cell  Volume 57, Issue 2, Pages (January 2015) DOI: /j.molcel Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 ZMP Regulates Expression of Tetrahydrofolate Genes
The purine intermediate ZMP (highlighted in pink) is a positive regulator of expression of tetrahydrofolate genes involved in one-carbon metabolism. ZMP can also be produced from ATP via the histidine biosynthesis pathway. A conserved riboswitch is activated by ZMP binding, leading to expression of metabolic genes highlighted in pink. GlyA (glycine hydroxymethyltransferase), FolD (5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase), Fhs (formate tetrahydrofolate ligase), PurH (AICAR formyltransferase/IMP cyclohydrolase). Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2015 Elsevier Inc. Terms and Conditions

Download ppt "ZMP: A Master Regulator of One-Carbon Metabolism"

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.
SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages 224-235 (January.

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.
HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly Ni-Ting Chiou, Ganesh Shankarling, Kristen W. Lynch.

HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly Ni-Ting Chiou, Ganesh Shankarling, Kristen W. Lynch.
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages 241-253 (March 2014) DOI: 10.1016/j.cell.2014.02.012 Copyright.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages 20-44 (January 2014) DOI: 10.1016/j.cell.2013.12.012.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
An Ancient Mechanism for Splicing Control: U11 snRNP as an Activator of Alternative Splicing Jens Verbeeren, Elina H. Niemelä, Janne J. Turunen, Cindy.

An Ancient Mechanism for Splicing Control: U11 snRNP as an Activator of Alternative Splicing Jens Verbeeren, Elina H. Niemelä, Janne J. Turunen, Cindy.
Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.
Conserved Bacterial RNase YbeY Plays Key Roles in 70S Ribosome Quality Control and 16S rRNA Maturation Asha Ivy Jacob, Caroline Köhrer, Bryan William Davies,

Conserved Bacterial RNase YbeY Plays Key Roles in 70S Ribosome Quality Control and 16S rRNA Maturation Asha Ivy Jacob, Caroline Köhrer, Bryan William Davies,
Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages 226-240 (August 2014) DOI: 10.1016/j.cmet.2014.07.001.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet
Transcriptional Control of Gene Expression by MicroRNAs Basel Khraiwesh, M. Asif Arif, Gotelinde I. Seumel, Stephan Ossowski, Detlef Weigel, Ralf Reski,

Transcriptional Control of Gene Expression by MicroRNAs Basel Khraiwesh, M. Asif Arif, Gotelinde I. Seumel, Stephan Ossowski, Detlef Weigel, Ralf Reski,
Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.
Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.

Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.
Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites Jason Gertz, Daniel Savic, Katherine E. Varley, E. Christopher.

Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites Jason Gertz, Daniel Savic, Katherine E. Varley, E. Christopher.
Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres Emilio Cusanelli, Carmina Angelica.

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres Emilio Cusanelli, Carmina Angelica.
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages 248-252 (April 2010) DOI: 10.1016/j.cmet.2010.03.008 Copyright © 2010.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,
Mitochondrial Disulfide Bond Formation Is Driven by Intersubunit Electron Transfer in Erv1 and Proofread by Glutathione Melanie Bien, Sebastian Longen,

Mitochondrial Disulfide Bond Formation Is Driven by Intersubunit Electron Transfer in Erv1 and Proofread by Glutathione Melanie Bien, Sebastian Longen,
The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages 558-573 (April.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.
The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.

The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.

Similar presentations

Ads by Google