1. The Mucinous Lung Tumor Signature is highly enriched in colorectal, stomach, pancreatic, lung (adenocarcinoma; LUAD), and breast cancers
The Mucinous Lung Tumor Signature is highly enriched in colorectal, stomach, pancreatic, lung (adenocarcinoma; LUAD), and breast cancers Expression of the Mucinous Lung Tumor Signature genes (143 genes) in different cancers is shown. RNA‐seq data from different cancers were obtained from multiple cancer cell lines (n = 598, Dataset EV4), which were reported previously (Klijn et al, 2015). Gene expression was measured in RPKM quantile‐normalized and log2‐transformed. The minimum of log2‐transformed values was set to 0. The expression of a signature gene in a tissue group (cancer type) was measured as the average of the log2‐transformed gene expression in the cell lines of the tissue group. Hierarchical clustering was performed using Pearson's correlation‐based distance and average linkage.Mucinous Lung Tumor Signature enrichment score for different cancers using Gene Set Enrichment Analysis (GSEA) is shown. Using the lymphoid cell lines as control, colorectal, stomach, lung AD, pancreas, breast, urinary bladder, head–neck, lung SqCC, and ovarian cancers were highly enriched with the Mucinous Lung Tumor Signature. Lung_AD: lung adenocarcinoma; Lung_LCC: lung large cell carcinoma; Lung_SqCC: lung squamous cell carcinoma; Lung_SCLC: small cell lung cancer.
Minzhe Guo et al. EMBO Mol Med. 2017;9:
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