1. What is the major conclusion of this paper?
presenilin 1 is likely the ϒ-secretase
Presenilin 1 can cleave Notch
Presenilin 1 can cleave APP
Presenilin 1 is important for intramembranous cleavage of Notch
None of the above

2. Pulse-chase experiments are used
To monitor the fate, stability, or movement of a molecule over a period of time
To monitor the cleavage of a protein by a protease
To label a protein with radioactive isotopes
To detect proteins expressed at very low levels
None of the above.

3. The authors used protease inhibitors to provide
definitive evidence that ϒ-secretase is involved in Notch processing
correlative evidence that ϒ-secretase is involved in Notch processing
evidence that a protease is involved in processing of both APP and Notch
evidence that the proteasome is involved in degradation of APP and Notch
None of the above

4. This study shows that Notch and APP are
proteins with similar functions
likely processed by ϒ-secretase
both important trans-membrane proteins
likely processed by α-secretase
related in functions