1. Seroreactivity of 38 Human Papillomavirus Types in Epidermodysplasia Verruciformis Patients, Relatives, and Controls 
Kristina M. Michael, Tim Waterboer, Herbert Pfister, Marisa Gariglio, Slawomir Majewski, Michel Favre, Michael Pawlita 
Journal of Investigative Dermatology 
Volume 130, Issue 3, Pages (March 2010)
DOI: /jid
Copyright © 2010 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
HPV antibody reactivity by HPV group in EV patients (n=32), their relatives (n=22), and controls (n=64 and 44, respectively). The box plots show the distribution of serum antibody reactivities measured by HPV multiplex serology and expressed as median fluorescence intensity (MFI, logarithmic scale). Sera from 32 EV patients, 22 first-degree relatives, and 64 (VERA 1, age- and sex-matched for 32 EV patients) and 44 (VERA 2, age- and sex-matched for 22 relatives) controls of a population-based cross-sectional nutrition study (VERA) were analyzed for antibodies to the L1 major capsid proteins of 38 HPV types and two control antigens (VP1 from human polyoma virus JC, CagA from Helicobacter pylori). HPV antigens were grouped by phylogeny. Phylogenetic PV genera are depicted in Greek letters (α for alpha, β for beta, γ for gamma, μ for mu, and ν for nu), species in numbers. The group α/μ/ν includes HPV types 1, 2, 3, 7, 10, 13, 16, 18, 27, 41, 57, 63, and 77, group β1 types 5, 8, 20, 24, and 36, group β2 types 9, 15, 17, 23, 38, and 107, group β3/4/5 types 49, 75, 76, 92, and 96, and group γ types 4, 48, 50, 60, 65, 88, 95, 101, and 103. The two control antigens constitute a separate group. Each data point represents the reactivity of one serum with one antigen. Boxes include the 25th–75th percentile of reactivities, and the line within shows the median. Whiskers below and above describe the 10th and 90th percentiles, and circles represent the 5th and 95th percentiles. Color code and size of the groups are indicated in the legend. Missing whiskers are because of small group sizes. CagA, cytotoxin-associated gene A; EV, epidermodysplasia verruciformis; HPV, human papillomavirus; JC, polyoma virus JC; MFI, median fluorescence intensity; VERA, Verbundstudie Ernährungserhebung und Risikofaktorenanalytik.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2010 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Seroprevalences by HPV group in EV patients (n=32), their relatives (n=22), and controls (n=64 and 44, respectively). MFI values were dichotomized as antibody positive or negative by applying antigen-specific cutoffs (200 MFI for HPV antigens, 500 MFI for control antigens). Sera from 32 EV patients, 22 first-degree relatives, and 64 (VERA 1, age- and sex-matched for 32 EV patients) and 44 (VERA 2, age- and sex-matched for 22 relatives) controls of a population-based cross-sectional nutrition study (VERA) were analyzed for antibodies to the L1 major capsid proteins of 38 HPV types and two control antigens (VP1 from human polyoma virus JC, CagA from Helicobacter pylori). HPV antigens were grouped by phylogeny. Phylogenetic PV genera are depicted in Greek letters (α for alpha, β for beta, γ for gamma, μ for mu, and ν for nu), species in numbers. The group α/μ/ν includes HPV types 1, 2, 3, 7, 10, 13, 16, 18, 27, 41, 57, 63, and 77, group β1 types 5, 8, 20, 24, and 36, group β2 types 9, 15, 17, 23, 38, and 107, group β3/4/5 types 49, 75, 76, 92, and 96, and group γ types 4, 48, 50, 60, 65, 88, 95, 101, and 103. The two control antigens constitute another group. The prevalence of antibody reactions against at least one HPV type or antigen within one group is shown. Color code and size of the groups are indicated in the legend. CagA, cytotoxin-associated gene A; EV, epidermodysplasia verruciformis; HPV, human papillomavirus; JC, polyoma virus JC; MFI, median fluorescence intensity; VERA, Verbundstudie Ernährungserhebung und Risikofaktorenanalytik.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2010 The Society for Investigative Dermatology, Inc Terms and Conditions