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Outcome of Donor Lymphocyte Infusion after T Cell–depleted Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic.

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Presentation on theme: "Outcome of Donor Lymphocyte Infusion after T Cell–depleted Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic."— Presentation transcript:

1 Outcome of Donor Lymphocyte Infusion after T Cell–depleted Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic Syndromes  Pramila Krishnamurthy, Victoria T. Potter, Linda D. Barber, Austin G. Kulasekararaj, Zi Yi Lim, Rachel M. Pearce, Hugues de Lavallade, Michelle Kenyon, Robin M. Ireland, Judith C.W. Marsh, Stephen Devereux, Antonio Pagliuca, Ghulam J. Mufti  Biology of Blood and Marrow Transplantation  Volume 19, Issue 4, Pages (April 2013) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 (A) Estimated OS for the pDLI cohort. OS calculated by the method of Kaplan-Meier demonstrated 80% 5-year survival after first pDLI. (B) Estimated EFS for the pDLI cohort. EFS calculated by the method of Kaplan-Meier demonstrated 65% 5-year survival after first pDLI. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 2 Estimated OS for the tDLI cohort, stratified by time to first DLI post-HSCT. Patients requiring tDLI at >6 months post-HSCT had a significantly superior OS after first tDLI compared with patients requiring therapy before 6 months. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

4 Figure 3 Estimated OS for the tDLI cohort, stratified by cytogenetic risk group at diagnosis [22,23]. OS at 5 years post-tDLI was estimated at 65% for good-risk patients, 33% for intermediate-risk patients, and 0% for poor-risk patients. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions


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