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Volume 86, Issue 3, Pages (September 2014)

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1 Volume 86, Issue 3, Pages 610-618 (September 2014)
Enhanced posttransplant management of patients with diabetes improves patient outcomes  Mira T. Keddis, Mireille El Ters, Emilio Rodrigo, Patrick Dean, Mariana Wohlfahrtova, Yogish C. Kudva, Elizabeth C. Lorenz, Fernando G. Cosio  Kidney International  Volume 86, Issue 3, Pages (September 2014) DOI: /ki Copyright © 2014 International Society of Nephrology Terms and Conditions

2 Figure 1 Trends in patient survival over time in patients with or without diabetes. (a) Kaplan–Meier plots of patient survival during the first 5 years post transplant in patients without diabetes mellitus (DM) (+—+) and in patients with DM transplanted between 1996 and 2000 (N=91, +— —+), between 2001 and 2002 (N=79, Δ…Δ), between 2003 and 2004 (N=104, ○—○), and between 2005 and 2007 (N=138, ▴—▴). (Log rank P<0.0001). (b) Five-year cumulative patient survival in patients without DM (hatched bars) and in patients with DM (black bars). Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

3 Figure 2 Incidence of fatal or nonfatal major adverse cardiac events (MACEs) during the first 5 years after kidney transplant in patients without diabetes mellitus (DM) (+—+) and in patients with DM transplanted in the following periods of time: 1996–2000 (N=91, +—+), 2001–2002 (N=79, Δ—Δ), 2003–2004 (N=104, ○—○), and 2005–2007 (N=138, ▴—▴). (Log rank P<0.0001). Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

4 Figure 3 Trends in post-transplant estimated glomerular filtration rate (eGFR) in kidney recipients with diabetes. (a) Changes over time in the proportion of patients with diabetes mellitus (DM) eGFR: <30ml/min per 1.73m2 (black bars); between 31 and 60 (hatched bars); or >60 (white bars). (b) Five-year mortality among recipients with DM and eGFR <30 (Δ—Δ), between 31 and 60 (○—○), or >60 (——). (Log rank P<0.0001). Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

5 Figure 4 Trends in post-transplant serum albumin levels in kidney recipients with diabetes. (a) Changes over time in the proportion of patients with diabetes mellitus (DM) with serum albumin levels at 1 year: <3.8g/dl (black bars), between 3.9 and 4.1g/dl (hatched bars), or >4.1g/dl (white bars). (b) Five-year mortality among recipients with DM and serum albumin <3.8 (●—●), 3.9–4.1 (+— —+), or >4.1g/dl (Δ—Δ). (Log-rank P<0.0001). Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions


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