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Volume 135, Issue 1, Pages (July 2008)

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Presentation on theme: "Volume 135, Issue 1, Pages (July 2008)"— Presentation transcript:

1 Volume 135, Issue 1, Pages 122-130 (July 2008)
Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes  Anna Kotronen, Leena Juurinen, Mirja Tiikkainen, Satu Vehkavaara, Hannele Yki–Järvinen  Gastroenterology  Volume 135, Issue 1, Pages (July 2008) DOI: /j.gastro Copyright © 2008 AGA Institute Terms and Conditions

2 Figure 1 Relationship between liver fat content and insulin clearance in the nondiabetic subjects (open circles) and the type 2 diabetic patients (closed circles). r = −0.41. P = .001. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

3 Figure 2 The relationship between liver fat content and hepatic insulin resistance. r = P = Symbols as in Figure 1. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

4 Figure 3 Relationship between liver fat content and (A) percent suppression of S-FFA concentrations by insulin (the gray line represents the nondiabetic subjects [r = 0.47; P = .005], and the black line represents the type 2 diabetic patients [r = 0.39; P = .025]. The difference between the intercepts is statistically significant [P = .003]). (B) Adipose tissue insulin sensitivity (r = 0.55; P < .0001). Symbols as in Figure 1. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions


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