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Published byΖηναις Ηλιόπουλος Modified over 5 years ago
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Glucose, insulin and potassium applied as perioperative hyperinsulinaemic normoglycaemic clamp: effects on inflammatory response during coronary artery surgery L. Visser, C.J. Zuurbier, F.J. Hoek, B.C. Opmeer, E. de Jonge, B.A.J.M. de Mol, H.B. van Wezel British Journal of Anaesthesia Volume 95, Issue 4, Pages (October 2005) DOI: /bja/aei220 Copyright © 2005 British Journal of Anaesthesia Terms and Conditions
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Fig 1 Time dependence of (a) plasma insulin and (b) plasma glucose concentrations in the control and GIK groups, respectively. The hyperinsulinaemic clamp period is indicated by the black horizontal bar. Data are presented as mean (sem). *P<0.05 between groups; †P<0.05 within group; two-way anova for repeated measurements with Bonferroni correction. British Journal of Anaesthesia , DOI: ( /bja/aei220) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions
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Fig 2 Scattergram showing all glucose measurements in GIK (clamp) and control (non-clamp) patients. Baseline measurements were taken at t=0, after which the hyperinsulinaemic normoglycaemic clamp was started in the GIK group. Glucose measurements in both groups were continued until 24 h after release of aortic cross-clamping. The horizontal line drawn at a glucose level of 2.2 mmol litre−1 represents the lower limit of normoglycaemia used by van den Bergheand colleagues.2 The horizontal line at a glucose level of 3 mmol litre−1 represents the lower glucose limit used in the present study (see Methods). The horizontal line at a glucose level of 4 mmol litre−1 shows the lower limit of the narrow range used as a buffer to prevent overshoot hyperglycaemia and hypoglycaemia. The horizontal line at a glucose level of 5.5 mmol litre−1 shows the upper limit of this buffer range. The horizontal line at a glucose value of 6.1 mmol litre−1 shows the upper limit of normoglycaemia used in the present study. British Journal of Anaesthesia , DOI: ( /bja/aei220) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions
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Fig 3 Time dependence of CRP production. Data are presented as mean (sem). *P<0.05 between groups; two-way anova for repeated measurements with Bonferroni correction. †P<0.05 between groups at separate time points. Note that at some measurement points the error bars are too small to be visible on the scale used. British Journal of Anaesthesia , DOI: ( /bja/aei220) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions
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Fig 4 Time dependence of SAA levels. Data are presented as mean (sem). *P<0.05 between groups; two-way anova for repeated measurements with Bonferroni correction. †P<0.05 between groups at separate time points. Note that at some measurement points the error bars are too small to be visible on the scale used. British Journal of Anaesthesia , DOI: ( /bja/aei220) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions
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