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Combination of alpha-stat strategy and hemodilution exacerbates neurologic injury in a survival piglet model with deep hypothermic circulatory arrest 

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Presentation on theme: "Combination of alpha-stat strategy and hemodilution exacerbates neurologic injury in a survival piglet model with deep hypothermic circulatory arrest "— Presentation transcript:

1 Combination of alpha-stat strategy and hemodilution exacerbates neurologic injury in a survival piglet model with deep hypothermic circulatory arrest  Takahiko Sakamoto, MD, David Zurakowski, PhD, Lennart F Duebener, MD, Shin’ichi Hatsuoka, MD, Hart G.W Lidov, MD, PhD, Gregory L Holmes, MD, Ulrich A Stock, MD, Peter C Laussen, MD, Richard A Jonas, MD  The Annals of Thoracic Surgery  Volume 73, Issue 1, Pages (January 2002) DOI: /S (01)03274-X

2 Fig 1 Comparison of near-infrared spectroscopy results between pH-strategy and hematocrit groups from baseline to the end of the cardiopulmonary bypass weaning period (off bypass). Oxyhemoglobin (HbO2) signal (A), deoxyhemoglobin (HHb) signal (B), total hemoglobin (HbT) signal (C), oxidized cytochrome a,a3 (CytO2) signal (D), and tissue oxygenation index (E). Time course: baseline (t1), start of cooling phase (t2), 20 minutes cooling (t3), 40 minutes cooling (t4), 5 minutes DCHA (t5), 30 minutes DCHA (t6), 60 minutes DCHA (t7), 5 minutes rewarming (t8), 20 minutes rewarming (t9), 40 minutes rewarming (t10), 10 minutes off bypass (t11), 30 minutes off bypass (t12), 1 hour off bypass (t13), 2 hours off bypass (t14), 3 hours off bypass (t15). Vertical bars represent standard deviations. (BL = baseline; DHCA = deep hypothermic circulatory arrest; DPF = differential pathlength factor.) The Annals of Thoracic Surgery  , DOI: ( /S (01)03274-X)

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