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Implication of HLA-G 5′ upstream regulatory region polymorphisms in idiopathic recurrent spontaneous abortions  Divya Agrawal, Swayam Prakash, Maneesh.

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Presentation on theme: "Implication of HLA-G 5′ upstream regulatory region polymorphisms in idiopathic recurrent spontaneous abortions  Divya Agrawal, Swayam Prakash, Maneesh."— Presentation transcript:

1 Implication of HLA-G 5′ upstream regulatory region polymorphisms in idiopathic recurrent spontaneous abortions  Divya Agrawal, Swayam Prakash, Maneesh Kumar Misra, Shubha R. Phadke, Suraksha Agrawal  Reproductive BioMedicine Online  Volume 30, Issue 1, Pages (January 2015) DOI: /j.rbmo Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

2 Figure 1 HLA-G 5′- upstream regulatory region single nucleotide polymorphism (minor allele frequency ≥ 2%) and 14bp insertion-deletion polymorphism in exon-8 of 3′-UTR define nine unique haplotype among North Indian population. The shaded cells (grey colour) represent minor allele, whereas cells with no-shading represent major allele. Reproductive BioMedicine Online  , 82-91DOI: ( /j.rbmo ) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

3 Figure 2 Linkage disequilibrium between pairs of 5′- upstream regulatory region single nucleotide polymorphism and 14bp insertion–deletion polymorphism in the HLA-G for combined cases of idiopathic recurrent spontaneous abortion and control women. The image was generated using HAPLOVIEW (version 4.2) programme using single nucleotide polymorphism with minor allele frequencies greater than 2%. Colour interpretations: dark red: strong linkage disequilibrium (linkage disequilibrium ≥ 2, D′ = 1); pink: moderate linkage disequilibrium (linkage disequilibrium ≥ 2, D′ < 1); and white: no linkage disequilibrium (linkage disequilibrium < 2, D′ < 1). LOD: log of the odds; D′: pairwise correlation between single nucleotide polymorphisms. Reproductive BioMedicine Online  , 82-91DOI: ( /j.rbmo ) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions


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