1. Volume 77, Issue 5, Pages 459-467 (March 2010)
Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms 
Ben Caplin, Dorothea Nitsch, Herpreet Gill, Richard Hoefield, Scott Blackwell, Douglas MacKenzie, Jackie A. Cooper, Rachel J. Middleton, Philippa J. Talmud, Peter Veitch, Jill Norman, David C. Wheeler, James M. Leiper 
Kidney International 
Volume 77, Issue 5, Pages (March 2010)
DOI: /ki
Copyright © 2010 International Society of Nephrology Terms and Conditions

2. Figure 1
Impact of the DDAH1 SNP rs on renal allograft mRNA expression and circulating ADMA concentrations. (a) Renal allograft DDAH1 mRNA levels stratified according to genotype at DDAH1 SNP rs DDAH1 mRNA values normalized to the geometric mean of β-actin, β2-microglobulin, and TATA-box binding protein. Horizontal bars: arithmetic mean. (b) Adjusted plasma asymmetric dimethylarginine (ADMA) concentrations in the European Atherosclerosis Relatives Study II (EARSII) and the London Arterial Calcification, Kidney and Bone Outcomes (LACKABO) subjects stratified by genotype at rs Plasma ADMA values were adjusted for age in LACKABO and age, case–control status and region of origin in EARSII. Solid bars, EARSII; hatched bars, LACKABO; y axis, log scale. Geometric mean of adjusted ADMA levels is shown; error bars, standard error of the geometric mean. No formal correction for multiple testing was made.
Kidney International  , DOI: ( /ki )
Copyright © 2010 International Society of Nephrology Terms and Conditions

3. Figure 2
Schematic representation and linkage disequilibrium plot of DDAH1 showing the relative positions of single-nucleotide polymorphisms (SNPs) examined in this study. DDAH1 is located at chromosome 1p22 (reverse strand). The rs polymorphism tags a significant portion of intron 1. Base numbering from database accession number NT_ Vertical bars, coding regions; black diamonds, SNPs. Linkage disequilibrium from HAPMAP-CEU population shown; plot.16 Black, r2=1; shades of gray, 0>r2>1; white, r2=0. DDAH2 (chromosome 6p21) variation is captured by a single SNP, rs
adapted from Haploview software
Kidney International  , DOI: ( /ki )
Copyright © 2010 International Society of Nephrology Terms and Conditions