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How Botryllus Chooses to Fuse

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Presentation on theme: "How Botryllus Chooses to Fuse"— Presentation transcript:

1 How Botryllus Chooses to Fuse
Gary W. Litman  Immunity  Volume 25, Issue 1, Pages (July 2006) DOI: /j.immuni Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Histocompatibility in a Urochordate
(A) Allorecognition by Botryllus. Colonies of Botryllus, which comprise asexually derived, genetically identical offspring (zooids), potentially contact each other in the course of the natural history of this urochordate. Fusion occurs through the ampullae, which are bud-shaped terminal projections of peripheral blood vessels. When colonies share at least one of two fusion-histocompatibility (FuHC) alleles, a single colony is formed that shares common circulation. (B) When colonies do not share FuHC alleles, a blood-based inflammatory reaction occurs in which cells migrate out of the ampullae and kill each other. siRNA-directed knockdown of fester prevents both fusion in compatible and rejection in incompatible colonies, underscoring the crucial role of fester in this ancient form of histocompatibility. Immunity  , 13-15DOI: ( /j.immuni ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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