1. PCSK9 Inhibitors and Statin Intolerance

3. Background and Historical Perspective "Statin Intolerance"

4. Multiple Challenges in Statin Selection

5. Statin Safety and Statin-Associated Side Effects

6. Definitions Degrees of Tolerability

7. Specific Questions to Ask Patient

8. Muscle Adverse Event Terminology

9. "Nocebo Effect"* Observed with Blinded Rechallenge GAUSS-3 Study

10. Statin Safety and Statin-Associated Side Effects 2018 Cholesterol Guidelines

11. Clinical Conversations and Assessments Describing Symptoms in Their Own Words

12. Tailoring Therapy and Consideration of Statin-Associated Side Effects

13. Real-World Data With PCSK9 Inhibitor Treatment Patient Experience

14. Implementation Recommendations 2018 Cholesterol Guidelines

15. Team-Based Approach

16. PCSK9 Inhibition

17. Patient Education Management With PCSK9 Inhibitors

18. Summary

19. Abbreviations