1. Transfusion-Related Acute Lung Injury
Ognjen Gajic, MD, MSc, S. Breanndan Moore, MD, FRCPI 
Mayo Clinic Proceedings 
Volume 80, Issue 6, Pages (June 2005)
DOI: /
Copyright © 2005 Mayo Foundation for Medical Education and Research Terms and Conditions

2. FIGURE 1
Pathogenesis of transfusion-related acute lung injury. The presence of antileukocyte antibodies and/or biologically active lipids from cell membrane fragments in donor blood triggers an inflammatory response, granulocyte activation, and degranulation and injury to the alveolar-capillary membrane. Activated macrophages secrete inflammatory cytokines that further perpetuate the inflammatory reaction. C = complement; HLA = human leukocyte antigen; IL = interleukin; LPS = lysophosphatidil choline; PAF = platelet activating factor; TNF = tumor necrosis factor; 5b, NA, NB = neutrophil antigens.
Mayo Clinic Proceedings  , DOI: ( / )
Copyright © 2005 Mayo Foundation for Medical Education and Research Terms and Conditions