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Volume 144, Issue 4, Pages e2 (April 2013)

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1 Volume 144, Issue 4, Pages 726-735.e2 (April 2013)
Levels of Antibodies Against Tissue Transglutaminase During Pregnancy Are Associated With Reduced Fetal Weight and Birth Weight  Jessica C. Kiefte–de Jong, Vincent W.V. Jaddoe, André G. Uitterlinden, Eric A.P. Steegers, Sten P. Willemsen, Albert Hofman, Herbert Hooijkaas, Henriette A. Moll  Gastroenterology  Volume 144, Issue 4, Pages e2 (April 2013) DOI: /j.gastro Copyright © 2013 AGA Institute Terms and Conditions

2 Figure 1 Simplified conceptual framework for the association between celiac disease autoantibodies and fetal growth. Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2013 AGA Institute Terms and Conditions

3 Figure 2 Flowchart of the study.
Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2013 AGA Institute Terms and Conditions

4 Figure 3 Carriers of the HLA-DQ2.5, -DQ2.2, or -DQ8 molecule according to anti-tTG levels. Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2013 AGA Institute Terms and Conditions

5 Figure 4 Difference in fetal growth SD score during pregnancy for intermediate and positive anti-tTG levels relative to mothers with negative anti-tTG levels (n = 7046; P = .02 for overall difference in growth curves between positive and intermediate levels relative to negative anti-tTG levels assessed by the F test; shaded area represents 95% CI; dashed line represents the reference group: negative anti-tTG). Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2013 AGA Institute Terms and Conditions

6 Supplementary Figure 1 Fractional polynomials model between anti-tTG titers and birth weight SD score (Y = B0 + B1 * 1/√anti-tTG + B2 * ln(anti-tTG) * Ln(anti-tTG); P < .01). Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2013 AGA Institute Terms and Conditions

7 Supplementary Figure 2 Maternal nutritional status as explanation for the association between anti-tTG levels and birth weight SD score (N = 7046; *P < .05; **P = .05 for difference in mean birth weight SD score relative to negative anti-tTG levels). Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2013 AGA Institute Terms and Conditions

8 Supplementary Figure 3 Maternal nutritional status as explanation for the association between anti-tTG levels and placental weight (N = 7046; *P < .05, **P = .10 for difference in placenta weight relative to negative anti-tTG levels). Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2013 AGA Institute Terms and Conditions


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