1. PAH Pathways: What Do the Data Tell Us?”

2. Program Goals

3. Evolution of Care for Patients With PAH

4. Introduction PAH Challenges

5. Pharmacologic Agents for PAH 3 Pathways

6. The Rationale for Combination Therapy

7. Goals and Perspectives in PAH Treatment

8. Therapies Targeting the Prostacyclin Pathway

10. GRIPHON

11. Paradigm Shift in PAH Treatment

14. GRIPHON Primary Endpoint

15. Primary Endpoint Composite of Death or a Complication Related to PAH Up to the End of the Treatment Period

21. Implications for Clinical Practice

22. Case Study Ms RG, 46 Years Old

23. Conclusion Selexipag in Clinical Practice

24. Abbreviations

25. Abbreviations (cont)

26. Abbreviations (cont)