1. Safety and efficacy of a heparin removal device: a prospective randomized preclinical outcomes study 
Joseph B Zwischenberger, MD, Weike Tao, MD, Donald J Deyo, DVM, Roger A Vertrees, PhD, Scott K Alpard, MD, Gerald Shulman, MD 
The Annals of Thoracic Surgery 
Volume 71, Issue 1, Pages (January 2001)
DOI: /S (00)

2. Fig 1
Changes in ACT during CPB and use of Protamine and the HRD in 60 kg (A), 80 kg (B), and 100 kg (C) weight subgroups (∗p values between groups at the end of HRD or protamine infusion were in 60-kg, 0.03 in 80-kg, and 0.08 in 100-kg weight subgroups, respectively; Δp = 0.01 vs baseline). ACT in both groups returned to baseline 60 minutes after the HRD run. (POD = postoperative day.)
The Annals of Thoracic Surgery  , DOI: ( /S (00) )

3. Fig 1
Changes in ACT during CPB and use of Protamine and the HRD in 60 kg (A), 80 kg (B), and 100 kg (C) weight subgroups (∗p values between groups at the end of HRD or protamine infusion were in 60-kg, 0.03 in 80-kg, and 0.08 in 100-kg weight subgroups, respectively; Δp = 0.01 vs baseline). ACT in both groups returned to baseline 60 minutes after the HRD run. (POD = postoperative day.)
The Annals of Thoracic Surgery  , DOI: ( /S (00) )

4. Fig 2
Plasma heparin concentration in HRD in 60-kg (A), 80-kg (B), and 100-kg (C) weight subgroups (∗p values between groups at the end of HRD or protamine infusion were in 60-kg, in 80-kg, and in 100-kg weight subgroups, respectively, Δp = 0.01 vs baseline). Heparin concentrations in both groups returned to baseline 60 minutes after the HRD run.
The Annals of Thoracic Surgery  , DOI: ( /S (00) )

5. Fig 2
Plasma heparin concentration in HRD in 60-kg (A), 80-kg (B), and 100-kg (C) weight subgroups (∗p values between groups at the end of HRD or protamine infusion were in 60-kg, in 80-kg, and in 100-kg weight subgroups, respectively, Δp = 0.01 vs baseline). Heparin concentrations in both groups returned to baseline 60 minutes after the HRD run.
The Annals of Thoracic Surgery  , DOI: ( /S (00) )

6. Fig 3
ATIII consumption pattern was not statistically different between groups throughout the study (Δp = 0.01 vs baseline). (POD = postoperative day.)
The Annals of Thoracic Surgery  , DOI: ( /S (00) )

7. Fig 4
Platelet count was similar in both groups during CPB, and remained above baseline through postoperative day 3 (∗p = 0.05 between groups; Δp = 0.01 vs baseline). (POD = postoperative day.)
The Annals of Thoracic Surgery  , DOI: ( /S (00) )

8. Fig 5
TEG index was not significantly different between the HRD and Protamine groups throughout the study. (POD = postoperative day.)
The Annals of Thoracic Surgery  , DOI: ( /S (00) )

9. Fig 6
Percent activated C3 was not significantly different between the HRD and Protamine groups throughout the study. (POD = postoperative day.)
The Annals of Thoracic Surgery  , DOI: ( /S (00) )