1. SRIA Roadmap 2019-2023 Jonathan Pearce
Management Board Meeting, 2-3 April 2019, Basel
SRIA Roadmap
Jonathan Pearce

2. SRIA Roadmap Procedure
December 2018
SRIA prioritisation workshop
February 2019
SAB feedback on prioritised topics
MB feedback on prioritised topics/Ranking
March 2019
Update of prioritised topics based on SAB and MB feedback
April 2019
Finalise actions and draft roadmap
May 2019
Publish roadmap

3. Funding mechanisms Research Calls Network Calls Workshops
Out of the box ideas

4. JPIAMR Calls 2014-2019 JPIAMR Past actions Year Funding scheme
Call Name
Priority topics
Investment
(M €)
2014
Projects
InnovaResistance
Therapeutics
8.1
2015
Repurposing Neglected Antibiotics
4.5
2016
Transmission and Selection of Resistance in Humans, Animals, and the Environment (ERAnet Cofund)
Transmission
(One Health)
28.2
Networks
AMR Networks
All
0.65
2017
Comparison of prevention, control and intervention strategies for AMR infections through multidisciplinary studies, including One Health approaches
Interventions (One Health)
11.5
2018
Therapeutics: New targets, compounds and tools
11.8
Surveillance
0.6
Building the Foundation of the JPIAMR Virtual Research Institute
0.5
2019
Development of diagnostic and surveillance tools, technologies and methods to detect antimicrobial resistance (AMR)
Diagnostics
Approx 18M
Total
65.85

5. JPIAMR Workshops 2015-2019 JPIAMR Past actions Year Workshops 2015
Diagnostics
Transmission dynamics intergovernmental
2016
New frontiers in AMR research
Transatlantic collaboration on clinical trials
The interplay between AMR surveillance and science
2017
Early discovery of new antibiotics
Environmental dimensions of AMR
JPIAMR Virtual Research Institute
2018
JPIAMR Funded Networks workshop
2019
Biocom AMR meeting (Industry)
VRI Network Start-up
Surveillance Network Start-up

6. JPIAMR Calls 2019-2023 JPIAMR Planned actions Year Funding scheme
Call Name
Priority topics
Investment
(M €)
2020
ERA Net
ERAnet Emerging Pollutants and Pathogens st calls
Environment
Transmission
2021
JPIAMR ACTION: AntimiCrobial Transmission InterventiONs
Intervention
ERAnet Emerging Pollutants and Pathogens 2019

7. JPIAMR Workshops 2019-2023 JPIAMR Planned actions Year Workshops 2019
Globalisation LAC
Globalisation Eastern Europe
AMR Funders
Globalisation Asia
2020
VRI Network Final
Surveillance Network Final

8. ERA-Net Aquatic Pollutants
Research Call, Year: 2020
ERA-Net Aquatic Pollutants
To fill existing key knowledge gaps regarding the environmental behaviour of new and emerging pollutants as well as pathogens in inland waters and the marine environment, and their impacts on ecosystems and human health
Collaboration of the three JPIs on Water, Oceans and Antimicrobial Resistance (AMR)
The AquaticPollutants proposal responds to the Horizon 2020 (H2020) Societal Challenge 5: Risks posed to human health and the environment by pollutants and pathogens present in water resources
No of funders = 32
No. countries participating = 24
No. JPIAMR countries participating = 18

9. ERA-Net Transmission/Interventions
Research Call, Year: 2021
ERA-Net Transmission/Interventions
One Health interventions to prevent or reduce the development and transmission of antimicrobial resistance (AMR)
General focus of the call: Interventions and Transmission
Societal Challenge 1: Health, demographic change and wellbeing

10. Proposed JPIAMR SRIA Roadmap Topics 2019-2023
Management Board Discussion

11. Ranking
1 = low priority 2 = medium priority 3 = high priority

12. Link to AMR drug development hub
Research Call, Year: 2022 THERAPEUTICS
Ranking: 2.6
Optimising existing drugs or drug combinations for the treatment of infections and/or prevention of the emergence/spread of resistance caused by priority pathogens on the WHO and OIE lists, including and up to preclinical development
Follows on from the 2nd JPIAMR Joint Call: Antimicrobial Resistance through the JPIAMR (projects funded )
Could involve IMI
Link to AMR drug development hub

13. Include fungal research
Research Call, Year: 2023 ALL PILLARS
Ranking: 3
Development of innovative, digital technologies for collection of microbiological, epidemiological, genetic, antibiotic and surveillance data for detection of transmission and surveillance of AMR in One Health settings
Follow up of 2019 Joint Research Call on Diagnostics and Surveillance (projects funded )
Include fungal research

14. Include fungal research
Workshop, Year: XXXX SURVEILLANCE
Network Call, Year: XXXX SURVEILLANCE
Ranking: 2
Workshop: Harmonisation and technical validation of diagnostic tools bringing together researchers, industry, policymakers, regulators, insurance providers and funders Network Call: Multidisciplinary networks to address the harmonisation and technical validation of diagnostic tools
Follow up of 2018 Network Call on Diagnostics and Surveillance (projects funded )
Include fungal research
The ValueDx project has just started. This workshop could be organised jointly with ValueDx.

15. Workshop/Network Call, Year: XXXX THERAPEUTICS
Ranking WS: 1.8
Ranking NC: 1.8
Workshop: Linking the global users of therapeutics and non-antibiotic therapies to identify new and alternative methods to fight infections and AMR Network Call: Global capacity building programmes in the area of early drug discovery of new targets, compounds and alternatives addressing pathogens on the WHO list of priority pathogens

16. Network Call, Year: XXXX ENVIRONMENT
Ranking: 2
Identifying and developing best practices in innovative technological, policy, social, economic and regulatory approaches to mitigate the transmission of antibiotic resistant organisms, genetic elements and residues to, from and within the environment

17. Network Call, Year: XXXX TRANSMISSION
Ranking: 2
Research methodologies to better define and quantify transmission routes of antimicrobial resistant organisms and mobile genetic elements to identify knowledge gaps in a One Health context

18. Workshop, Year: XXXX SURVEILLANCE
Research Call, Year: XXXX SURVEILLANCE
Ranking WS: 1.8
Ranking RC: 1.8
Workshop: Development of a globally integrated One Health surveillance system of antibiotic resistant genes and bacteria, and antibiotic usage with the goal of inter-sectoral coordination including the healthcare setting and community Research Call: Development of a globally integrated One Health surveillance system of antibiotic resistant bacteria and antibiotic usage

19. Network Call, Year: XXXX ENVIRONMENT
Not ranked
Collection of robust quantitative and qualitative data to develop risk prediction models

20. Network Call, Year: XXXX INTERVENTIONS
Not ranked
Building bridges between One Health areas to develop guidance and shared measures and standards to assess and implement interventions

21. Include the environmental impact of animal husbandry
Workshop, Year: XXXX INTERVENTIONS TRANSMISSION
Ranking: 1.7
Harmonisation of non-antibiotic approaches and strategies to replace, control or minimise the use of antibiotics in early life animal husbandry
Should be followed by a research call to have the impact this topic requires
Introduce a working group with a focus to identify best practises in this field
Include the environmental impact of animal husbandry
Should be opened to southern partners
Question: should it be followed by a network call? Then a research call?

22. Network Call, Year: XXXX THERAPEUTICS
Ranking: 1.6
Early drug discovery for capacity building in the discovery of new targets, compounds and alternatives
There are also gaps in research on how to optimise and ease clinical trials for new therapeutics, we suggest to include these in this action. The risk of emergence of resistance to the new compounds alternatives should be considered.

23. Hackathon: Brainstorming session to find new ways to tackle AMR
Out of the Box, Year: XXXX One Health
New topic
Proposed by SAB
Hackathon: Brainstorming session to find new ways to tackle AMR
Juniors (e.g. postdocs) will organise and invite ‘unusual suspects’ (a broader audience)
Travel funds should be given to young people
This could take the form of workshops to address certain questions
This would enhance the generation of innovative ideas and solutions
Could potentially lead to a future JPIAMR action, e.g. research call, network call, workshop