1. Volume 91, Issue 4, Pages 728-738 (August 2016)
In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells 
Hedong Li, Gong Chen 
Neuron 
Volume 91, Issue 4, Pages (August 2016)
DOI: /j.neuron
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Different Approaches to Generate New Neurons In Vitro and In Vivo
The in vitro approaches include: (1) using somatic cells such as skin fibroblasts to first reprogram into stem cells and then differentiate into neurons; (2) using somatic cells to directly trans-differentiate into neurons; (3) isolating stem cells or progenitor cells and differentiating into neurons in culture. These in vitro differentiated neurons or progenitor cells need to be transplanted into the CNS for neural repair. The in vivo approaches include modulating endogenous neural stem cells and in vivo reprogramming of internal glial cells to generate new neurons.
Neuron  , DOI: ( /j.neuron )
Copyright © 2016 Elsevier Inc. Terms and Conditions

3. Figure 2
In Vivo Reprogramming Is Fundamentally Different from Killing Reactive Glial Cells
In vivo reprogramming is a constructive strategy to regenerate functional neurons out of reactive glial cells, whereas killing reactive glial cells is a destructive process.
Neuron  , DOI: ( /j.neuron )
Copyright © 2016 Elsevier Inc. Terms and Conditions