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Immunotherapy for Advanced Melanoma

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Presentation on theme: "Immunotherapy for Advanced Melanoma"— Presentation transcript:

1 Immunotherapy for Advanced Melanoma
Lei Fang, Anke S. Lonsdorf, Sam T. Hwang  Journal of Investigative Dermatology  Volume 128, Issue 11, Pages (November 2008) DOI: /jid Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Strategy for immunotherapy of melanoma. CTL, cytotoxic T lymphocyte; DLN, draining lymph node; PBMC, peripheral blood mononuclear cells; CTLA, cytotoxic T lymphocyte antigen; TIL, tumor-infiltrating lymphocyte; HSC, hematopoietic stem cell. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Skin dermatitis following treatment with anti-CTLA-4 mAb as a single agent as described in Jaber et al. (2006). (a) Photodistributed macules and papules on face and neck, and (b) erythematous papules with Koebner-like phenomenon elicited by the trauma of scratching. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 3 Response of a melanoma tumor to a lymphodepleting chemotherapy regimen combined with adoptive transfer of tumor-infiltrating T cells (Dudley et al., 2002a). (photo courtesy of Dr Steven A. Rosenberg, Surgery Branch, NCI). Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions


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