1. Volume 11, Issue 6, Pages 817-833 (June 2004)
Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula 
Daniel J Edwards, Brian L Marquez, Lisa M Nogle, Kerry McPhail, Douglas E Goeger, Mary Ann Roberts, William H Gerwick 
Chemistry & Biology 
Volume 11, Issue 6, Pages (June 2004)
DOI: /j.chembiol

2. Figure 1
Structures of Metabolites Isolated from Jamaican Strain of Lyngbya majuscula and Assembly of Partial Structures A–F of Jamaicamide A
(A) Structures of hectochlorin and jamaicamide A–C, four metabolites isolated from this Jamaican strain of Lyngbya majuscula.
(B) Partial structures A–F of jamaicamide A (2) derived from 1H-1H COSY, 1H-13C HSQC, HSQC-COSY, and 1H-13C HMBC data.
(C) Assembly of partial structures A–F in jamaicamide A (2). Double-headed arrows represent 3JHH couplings, single-headed arrows represent important 2,3JCH couplings from HMBC, dashed arrows represent key 1H-15N HMBC correlations, and bolded arrow represents a key ACCORD-1,1-ADEQUATE correlation (H-18 to C-19). The boxed letters indicate the original partial structure designations.
Chemistry & Biology  , DOI: ( /j.chembiol )

3. Figure 2 Biosynthetic Precursors of Jamaicamide A
(A) Biosynthetic precursors of jamaicamide A (2).
(B) Expansions of the 13C NMR spectrum of jamaicamide A (2) isolated from cultures provided with [13C3,15N]β-Ala. Coupling constants (2JCC and 2JNC) indicate intact incorporation of the labeled β-Ala precursor.
Chemistry & Biology  , DOI: ( /j.chembiol )

4. Figure 3
Biosynthetic Gene Cluster and Proposed Biosynthesis of Jamaicamides A and B
(A) Map and gene arrangement of the ∼58 kbp jam gene cluster from L. majuscula JHB. Inserts of five fosmids containing the jam gene cluster are shown (asterisks indicate those fosmids sequenced during the current study; size of fosmid inserts indicated in parentheses).
(B) Proposed biosynthesis of jamaicamide A (2, R = Br) or B (3, R = H). The timing of bromination and chlorination is uncertain. JamB, a fatty acid desaturase, is likely involved in formation of the 5-hexenoic and 5-hexynoic acid precursors.
Chemistry & Biology  , DOI: ( /j.chembiol )

5. Figure 4
Substrate-Dependent ATP-PPi Exchange Activity for JamA and JamO(A) Domains
(A) JamA domain, (B) JamO(A) domain. Results presented represent the average from duplicate experiments. See Experimental Procedures for details.
Chemistry & Biology  , DOI: ( /j.chembiol )