1. Advances in Alport Syndrome

2. Alport Syndrome (AS)

3. AS Is Often Undiagnosed or Misdiagnosed

4. Genetic Mutations in AS

5. Type IV Collagen Networks

6. AS Prevalence

7. Alport Nephropathy Early and Accurate Diagnosis Is Critical

8. Early Diagnosis and Management of AS Can Improve Prognosis

9. Current Approaches for AS

10. Early Treatment With ACEI Preserves Renal Function in Children With CKD

11. CKiD Study -- Proteinuria is Major Risk Factor

12. Chronic Inflammation Plays a Central Role in CKD Progression

13. Bardoxolone Methyl Targets the NF-κB Cascade

14. Bardoxolone Methyl in Alport Syndrome CARDINAL Phase 2/3 Study Efficacy Results

15. Bardoxolone Methyl in Alport Syndrome CARDINAL Phase 2/3 Study Safety Results

16. Abbreviations

17. Abbreviations (cont)